Use of a citrate solution for affinity chromatographic purification of crp using phosphocholine and derivatives thereof
AssigneePentracor GmbH
InventorsAhmed SHERIFF, Birgit VOGT, Stephan MATTECKA
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Abstract
The invention relates to the use of a citrate solution for affinity-chromatographic removal of C-reactive protein (CRP) from biological fluids, wherein the CRP is affinity-chromatographically removed using (Ca2+-dependent) binding of CRP to a column material functionalized with ω-phosphonooxyalkyl ammonium groups and/or with ω-ammoniumalkoxy-hydroxy-phosphoryloxy groups.
Claims11
A method for affinity-chromatographic removal of CRP from a biological fluids comprising running the biological fluid through a column material functionalized with a ω-phosphonooxyalkyl ammonium groups and/or with ω-ammoniumalkoxy-hydroxy-phosphoryloxy groups, wherein the citrate solution serves as a binding buffer.
Dependencies are inferred from the claim text.