Endovascular Nerve Monitoring Devices and Associated Systems and Methods

A system, comprising:

• a shaft including a proximal portion and a distal portion, wherein the shaft is configured to intravascularly locate the distal portion at a treatment site within a renal blood vessel of a human patient;
• a balloon at the distal portion of the shaft, wherein the balloon is transformable between a delivery state and a deployed state, and wherein, in the deployed state, the balloon is configured to provide non-target tissue with protection from neuromodulation;
• a lumen extending distally from a proximal portion of the shaft to an opening positioned along a portion of the shaft within the balloon;
• a first electrode positioned on the outer surface of the balloon and extending about at least a portion of the circumference of the balloon;
• a second electrode positioned on the outer surface of the balloon and extending about at least a portion of the circumference of the balloon, wherein the first electrode is spaced apart from and electrically isolated from the second electrode along the balloon;
• wherein, in the deployed state, the balloon is sized and shaped to place the first electrode and the second electrode in apposition with an inner wall of the renal blood vessel;
• and
• wherein the first and second electrodes are configured to—
• deliver therapeutic neuromodulation to renal nerves proximate the treatment site, and
• stimulate nerves and/or record nerve activity at the treatment site.

A system, comprising:

• a shaft including a proximal portion and a distal portion, wherein the shaft is configured to intravascularly locate the distal portion at a treatment site within a renal blood vessel of a human patient;
• an outer balloon at the distal portion of the shaft, wherein the outer balloon is transformable between a first delivery state and a first deployed state, and wherein, in the first deployed state, the outer balloon is configured to provide non-target tissue with protection from neuromodulation;
• an inner balloon positioned within the outer balloon, wherein the inner balloon is transformable between a second delivery state and a second deployed state, and wherein, in the second deployed state, the inner balloon is configured to provide therapeutic neuromodulation to nerves proximate the treatment site;
• a first electrode positioned on the outer surface of the outer balloon and extending about at least a portion of the circumference of the outer balloon;
• and
• a second electrode positioned on the outer surface of the outer balloon and extending about at least a portion of the circumference of the outer balloon,
• wherein the first electrode is spaced apart from and electrically isolated from the second electrode along the outer balloon,
• wherein the first and second electrodes are configured to stimulate nerves and/or record nerve activity at the treatment site.