Devices and methods for intraluminal retention and drug delivery

A device for drug delivery comprising:

• a tubular housing configured for intraluminal deployment into a human or animal subject;
• at least one reservoir contained within the housing, the at least one reservoir having an actuation end and a release end and containing at least one drug formulation;
• a plug within the at least one reservoir and moveable from the actuation end toward the release end;
• an actuation system operably configured to drive the plug and displace the at least one drug formulation from the reservoir;
• and
• a retention sleeve that comprises at least two arms, each arm having a first end and a second end, the first ends being affixed to the housing and the second ends being affixed to a ring positioned about the housing and slideable between a deployment position in which the at least two arms are adjacent the housing and a retention position in which the at least two arms are outwardly expanded.

A method of drug delivery comprising:

• providing a drug delivery device that comprises:
• a housing,
• at least one retention member affixed to the housing,
• at least one reservoir within the housing, the at least one reservoir having a release end and an actuation end and containing at least one drug formulation, and
• a plug within the at least one reservoir and moveable from the actuation end toward the release end;
• transforming the retention member from a non-stressed position into a deployment position;
• deploying the device into a mucosal lumen of a human or animal subject;
• transforming the retention member from the deployment position into a retention position;
• and
• actuating an actuation system to drive the plug and displace the at least one drug formulation out of the at least one reservoir while the device is retained in the mucosal lumen.

A method of drug delivery comprising:

• providing a drug delivery device that comprises:
• a tubular housing,
• a retention sleeve having at least two arms, each arm having a first end and a second end, the first ends being affixed to the housing and the second ends being affixed to a ring positioned about the housing,
• at least one reservoir within the housing;
• inserting the device into a mucosal lumen of a human or animal subject;
• sliding the ring to outwardly expand the at least two arms of the retention sleeve into a retention position;
• and
• actuating an actuation system to drive the at least one drug formulation out of the at least one reservoir.