Systems and methods for peritoneal dialysis having point of use dialysis fluid preparation using water accumulator and disposable set

A peritoneal dialysis system comprising:

• a water purifier;
• a cycler including a pump actuator;
• a disposable set operable with the cycler, the disposable set including
• a pumping cassette including a pump chamber placeable in operable communication with the pump actuator,
• a heater/mixing container in fluid communication with the pumping cassette, and
• a water accumulator in fluid communication with the pumping cassette and the water purifier, and
• which is configured to cause the water purifier to pump water purified by the water purifier towards the water accumulator while (i) the pump actuator is actuating the pump chamber to pump fresh dialysis fluid from the heater/mixing container during a fill phase, (ii) treatment is in a dwell phase, or (iii) the pump actuator is actuating the pump chamber to pump used dialysis fluid from the pumping cassette during a drain phase.

A peritoneal dialysis system comprising:

• a water purifier including a water outlet connector, a water recirculation connector, and an internal recirculation loop from the water outlet connector to the water recirculation connector;
• a cycler;
• and
• a disposable set operable with the cycler, the disposable set including
• a pumping cassette including a water inlet port,
• a water line in fluid communication with the water inlet port and the water outlet connector, the water line including at least one sterile sterilizing grade filter, and
• a recirculation line in fluid communication with the water line downstream from the sterile sterilizing grade filter and the water recirculation connector, wherein the recirculation line and the internal recirculation loop absorb pressure upon a failure of the at least one sterile sterilizing grade filter.

A disposable set for operation with first and second concentrate containers in fluid communication with first and second concentrate container connectors, the disposable set comprising:

• a pumping cassette including a patient line port, a drain line port, a water inlet port, a heater/mixing port, a first concentrate port, and a second concentrate port;
• a patient line in fluid communication with the patient line port;
• a drain line in fluid communication with the drain line port;
• a water line in fluid communication with the water line port;
• a heater/mixing container in fluid communication with the heater/mixing port;
• a first concentrate line in fluid communication with the first concentrate port, the first concentrate line terminating at a first concentrate line connector having a first configuration for mating with the first concentrate container connector;
• and
• a second concentrate line in fluid communication with the second concentrate port, the second concentrate line terminating at a second concentrate line connector having a second, different configuration for mating with the second concentrate container connector, such that (i) the first concentrate line connector cannot mate with the second concentrate container connector, and (ii) the second concentrate line connector cannot mate with the first concentrate container connector.