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US 2017/0319751 A1Published application
Multiphase Gel
AssigneeBVW Holding AG
InventorsMichael Milbocker, Lukas Bluecher
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AssigneeBVW Holding AG
InventorsMichael Milbocker, Lukas Bluecher
Estimating the term…
Disclosed are hydrogels polymerized with or around a solid biofunctional moiety, biodegradable or permanent, designed to be implantable in a mammalian body, intended to block or mitigate the formation of tissue adhesions, and intended to aid in functional healing. The hydrogels of the present invention are characterized by comprising multiphasic structural elements: a) at least one gel phase, b) at least one solid phase, c) optional polymeric chains connecting gel and solid phases, d) optional shape designs that provide for an interpenetrating geometry between gels and solids, e) optional shape designs that enhance a tissue-hydrogel interface, and f) optional shape designs that provide a biofunctional aspect. The hydrophobicity of the various phases is chosen to reduce tissue adhesion and enhance tissue healing. The morphology of the polymers comprising the gel phase is typically of high molecular weight and has morphology that encourages entanglement. Useful polymeric structures include branching chains, comb or brush, and dendritic morphologies.
A composition comprising discrete phases, comprising at least two of the following:
A composition comprising gel phase and solid phase wherein the solid phase is geometrically homologous to genus 1.
A composition comprising a gel phase comprising the polymerization product of a prepolymer of polysaccharide and a chain extender comprising a moiety consisting of multiple functional hydroxyl groups or amine groups and a solid phase comprising a polyurethane containing at least one hydrolysable group.
A composition formed by the copolymerization of a polysaccharide and a trifunctional polyurethane prepolymer, wherein the addition of water to this copolymerization product results in a gel, and said gel is intersperse with a solid phase.
A composition comprising discrete phases, comprising at least two of the following:
A composition comprising gel and solid phases, wherein the gel phase possesses a geometry of genus N and the solid phase possesses a genus of between 1/N to 1/1,000,000N.
A multiphasic gel construct in which a solid phase is distributed in a gel phase, wherein the dimensional freedom on the gel phase is reduced by the solid phase.
A multiphasic gel comprising:
Dependencies are inferred from the claim text.