Composite polymeric nanofibers for skin regeneration
OwnerMohammad RAOUFIinventor
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Abstract
A method for preparing a skin regeneration scaffold is disclosed. The method may include preparing a polymer solution by dissolving a biopolymer in a solvent, and subjecting the polymer solution to a template-assisted extrusion process with a nanoporous material as a template in order to produce polymer nanofibers. Furthermore, the method includes fabricating a multilayer composite nanofibrous scaffold using the polymer nanofibers. The composite nanofibrous scaffold may be seeded with cells. In some cases, the cells may be selected from autologous cells, allogeneic cells, or combinations thereof.
Claims24
A method of preparing a skin, regeneration scaffold, the method comprising:
- preparing a polymer solution by dissolving, a biopolymer in a solvent;
- subjecting the polymer solution to a template-assisted extrusion process with a nanoporous material as the template in order to produce polymer nanofibers;
- and
- fabricating a multilayer composite nanofibrous scaffold using the polymer nanofibers.
A skin substitute, the skin substitute comprising a multilayer composite nanofibrous scaffold seeded with keratinocytes and fibroblasts cells.
Dependencies are inferred from the claim text.