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US 2017/0319741 A1Published application
Porous Polysaccharide Scaffold Comprising Nano-Hydroxyapatite and Use for Bone Formation
AssigneesInstitut National De La Sante Et De La Recherche Medicale (Inserm), Universite de Bordeaux II Victor Segalen, Universite Paris Diderot—Paris 7
InventorsJoelle Amedee, Didier Letourneur, Catherine Le Visage, Sidi Mohammed Derkaoui, Jean-Christophe Fricain, Sylvain Catros
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Abstract
The present invention relate to three dimensional porous polysaccharide matrices able to induce mineralisation of a tissue in osseous site, as well as in non-osseous site, in the absence of stem cells or growth factors.
Claims19
1-24. (canceled)
A porous polysaccharide scaffold method obtained by:
- i) preparing an alkaline aqueous solution comprising at least one polysaccharide, a cross-linking agent and a porogen agent,
- ii) transforming the solution into a hydrogel by placing said solution at a temperature from 4° C. to 80° C. for a sufficient time to allow cross-linking of said at least one polysaccharide,
- iii) submerging said hydrogel into a solvent, and
- iv) washing the porous polysaccharide scaffold obtained at step iii),
- wherein the alkaline aqueous solution of step i) further comprises hydroxyapatite.
2 more elements
Dependencies are inferred from the claim text.