Bioactive Wound Dressing and Teeth Coating Based on Morphogenetically Active Amorphous Calcium Polyphosphate

Abstract

This invention relates to a method for sealing dentinal tubules exposed at the tooth surface as a consequence of enamel defects, based on amorphous calcium polyphosphate (Ca-polyP) nano- or microparticles that strongly bind both to tooth enamel, cementum and dentin surfaces. The inventive method can also be used for the production of morphogenetically active tooth implants. A further aspect of this invention concerns the incorporation of such nano- or microparticles, after encapsulation of retinol (“retinol/aCa-polyP nano- or microspheres”), into wound dressings and related materials that are made, e.g., by electrospinning. The resulting, inventive retinol/aCa-polyP nano- or microspheres fiber mats show antimicrobial and wound healing properties and was found to increase the expression of the genes encoding for leptin and the leptin receptor, as well as the fatty acid binding protein 4 (FABP4) in a synergistic manner. This inventive material is the first material that can be used to promote wound healing through affecting the leptin/leptin receptor expression.

Dependencies are inferred from the claim text.