Method for preparing organic fluoride-aliphatic compound and method for purifying organic fluoride-aliphatic compound

A method for purifying an organic fluorinated aliphatic compound, the method comprising:

• purifying the organic fluorinated aliphatic compound through solid phase extraction (SPE) carried out by using an ion exchange SPE cartridge represented by the following Chemical Formula 2:
• wherein the solid support is either a polymer containing a phenyl group and C1-C20 hydrocarbon, or silica;
• A is null when the solid support is the polymer, or a phenyl or a C1-C20 hydrocarbon group when the solid support is the silica;
• and
• B is an organic cation or an organic anion;
• the organic cation is selected from the group consisting of:
• (i)
• wherein E is nitrogen or phosphorus, and R1, R2 and R3 is the same or different from one another, and each represents C1-C20 hydrocarbon group;
• (ii);
• and
• (iii) a C2-C20 heteroaromatic cation having at least two nitrogen atoms, nitrogen and oxygen, or nitrogen and sulfur, and having a substituent of a C1-20 hydrocarbon group at the position of one nitrogen atom,
• and the organic anion is sulfonic acid (—SO3−) or carboxylic acid (—COO−).

A method for preparing a radiopharmaceutical, the method comprising:

• eluting [18F] fluoride through a backflow-preventing reaction container included in a cassette;
• drying the eluent in the backflow-preventing reaction container;
• and
• supplying a radiopharmaceutical precursor and a reaction solvent to the backflow-preventing reaction container and allowing the dried [18F] fluoride to react with the radiopharmaceutical precursor in the presence of the reaction solvent,
• wherein the backflow-preventing reaction container comprises a first line for supplying reagents for preparing the radiopharmaceutical and a second line for providing a vacuum state, the end point of the first line is present at least at a position higher than the surface of the reagents for preparing the radiopharmaceutical supplied to the backflow-preventing reaction container.