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US 2017/0319719 A1Published application
J-Aggregate Forming Nanoparticle
AssigneeUniversity Health Network
InventorsGang Zheng, Elizabeth Huynh, Kenneth Ng, Mojdeh Shakiba, Robert Weersink, Brian Wilson
Life of this patent
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Abstract
There is provided herein a nanovesicle having a bilayer comprising a saturated first phospholipid and no more than about 15 molar % of a second phospholipid covalently conjugated to a J-aggregate forming dye.
Claims20
A method of monitoring temperature at a target site comprising:
- a. providing a nanovesicle at the target site, the nanovesicle having a bilayer comprising (i) a saturated first phospholipid and (ii) no more than about 15 molar % of a second phospholipid covalently conjugated to a J-aggregate forming dye;
- and
- b. monitoring absorbance at the target site,
- wherein a blue shift in absorbance is indicative of temperature at the target site being higher than a predetermined temperature, the predetermined temperature corresponding to a transition temperature of the saturated first phospholipid, and
- wherein a red shift in absorbance is indicative of temperature at the target site being lower than the predetermined temperature.
2 more elements
A method of monitoring temperature at a target site comprising:
- a. providing a nanovesicle at the target site, the nanovesicle having a bilayer comprising (i) a saturated first phospholipid and (ii) no more than about 15 molar % of a second phospholipid covalently conjugated to a J-aggregate forming dye;
- and
- b. monitoring a photoacoustic signal at the target site,
- wherein a lack of a photoacoustic signal is indicative of temperature at the target site being higher than a predetermined temperature, the predetermined temperature corresponding to a transition temperature of the saturated first phospholipid, and
- wherein a presence of a photoacoustic signal is indicative of temperature at the target site being lower than the predetermined temperature.
2 more elements
A method of monitoring temperature at a target site comprising:
- a. providing a nanovesicle at the target site, the nanovesicle having a bilayer comprising (i) a saturated first phospholipid and (ii) no more than about 15 molar % of a second phospholipid covalently conjugated to a J-aggregate forming dye;
- and
- b. monitoring a fluorescence signal at the target site,
- wherein a presence of a blue shifted fluorescence signal is indicative of temperature at the target site being higher than a predetermined temperature, the predetermined temperature corresponding to a transition temperature of the saturated first phospholipid, and
- wherein a presence of a red-shifted fluorescence signal is indicative of temperature at the target site being lower than the predetermined temperature.
2 more elements
Dependencies are inferred from the claim text.