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AssigneeNational Center for Geriatrics and Gerontology
InventorYuji YOSHIIKE
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The present invention provides a tau protein aggregation inhibitor. In addition, a therapeutic agent or a preventive agent for tauopathy, including a tau protein aggregation inhibitor, and a method for screening for a tau protein aggregation inhibitor, are also provided. The problems are solved by a tau protein aggregation inhibitor including a fluorone dye or a pharmaceutically acceptable salt thereof. Moreover, the problems are also solved by a method for screening a tau protein aggregation inhibitor, wherein the method includes: (1) a step of preparing transgenic Drosophila that express a human tau protein in neurons, (2) a step of administering a candidate compound to the transgenic Drosophila, and (3) a step of measuring the motor function of the transgenic Drosophila that have been administered with the candidate compound in the step (2).
1-8. (Canceled)
A method for inhibiting aggregation of tau proteins, comprising contacting the tau proteins with a fluorone dye or a pharmaceutically acceptable salt thereof.
A method for treating or preventing tauopathy in a subject, comprising administering to the subject an effective amount of a fluorone dye or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.