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US 2017/0319711 A1Published application
Antibody-drug conjugates
AssigneeWyeth
InventorsHans-Peter Gerber, John Francis DiJoseph, Kiran Manohar Khandke, Kimberly Ann Marquette, Puja Sapra, Lioudmila Gennadievna Tchistiakova
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Abstract
Disclosed are anti-5T4 antibody drug conjugates and methods for preparing and using the same.
Claims8
An antibody-drug conjugate of the formula:
- Ab-(LU-D)p
- or a pharmaceutically acceptable salt thereof wherein;
- (a) Ab is an anti-5T4 antibody or antigen binding portion thereof, comprising:
- (i) a VH CDR1 region as shown in SEQ ID NO:
- 5,
- (ii) a VH CDR2 region as shown in SEQ ID NO:
- 6,
- (iii) a VH CDR3 region as shown in SEQ ID NO:
- 7;
- (iv) a VL CDR1 region as shown in SEQ ID NO:
- 8,
- (v) a VL CDR2 region as shown in SEQ ID NO:
- 9, and
- (vi) a VL CDR3 region as shown in SEQ ID NO:
- 10,
- (b) LU is a linker unit selected from the group consisting of maleimidocaproyl and maleim idocaproyl-Val-Cit,
- (c) p is an integer from about 1 to about 8, and
- (d) D is a Drug unit selected from the group consisting of MMAE, MMAD, and MMAF.
15 more elements
Dependencies are inferred from the claim text.