Combination Of Drugs With Protein-Binding Prodrugs
AssigneeKtb Tumorforschungsgesellschaft Mbh
InventorFelix KRATZ
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Abstract
The present invention relates to a composition and a combination comprising at least one first drug and at least one protein-binding prodrug, wherein the protein-binding prodrug comprises a protein-binding group, a second drug, and a linker that can be cleaved hydrolytically, enzymatically, or in a pH-dependent manner in the body, as well as to a kit and a pharmaceutical composition comprising said composition or combination.
Claims19
A composition comprising a combination of at least one first drug and at least one protein-binding prodrug, wherein the protein-binding prodrug comprises a protein-binding group, a second drug, and a linker that can be cleaved hydrolytically, enzymatically, or in a pH-dependent manner, and wherein the at least one first drug and the second drug contained in the prodrug are the same or different.
A method for enhancing efficacy and tolerability of a drug in a subject comprising simultaneously or sequentially administering to the subject a combination of at least one first drug and at least one protein-binding prodrug, wherein the protein-binding prodrug comprises a protein-binding group, a second drug, and a linker that can be cleaved hydrolytically, enzymatically, or in a pH-dependent manner.
Dependencies are inferred from the claim text.