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US 2017/0319701 A1Published application
Drug-containing implants and methods of use thereof
AssigneeThe Trustees of the University of Pannsylvania
InventorsSteven Siegel, Karen Winey
Life of this patent
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Abstract
The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA). The present invention also provides methods of maintaining a therapeutic level of a drug in a subject, releasing a therapeutic drug at a substantially linear rate, and treating schizophrenia and other diseases and disorders, utilizing implants of the present invention.
Claims25
1-81. (canceled)
An implant comprising:
- a therapeutic drug and a polymer, said polymer comprising polylactic acid (PLA) and optionally polyglycolic acid (PGA) in a PLA:PGA molar ratio between 50:50 and 100:0, wherein said therapeutic drug is present in an amount of about 10%-30% (w/w), wherein the presence of said polymer in said implant extends the release duration of said therapeutic drug in a subject, and wherein said therapeutic drug is risperidone.
An implant comprising:
- a therapeutic drug and a polymer, said polymer comprising polylactic acid (PLA) and polyglycolic acid (PGA) in a PLA:PGA molar ratio between 75:25 and 85:15, wherein said therapeutic drug is present in an amount of about 10%-60% (w/w) and said polymer is present in an amount of about 40-90% (w/w), wherein the presence of said polymer in said implant extends the release duration of said therapeutic drug in a subject, and wherein said therapeutic drug is risperidone.
Dependencies are inferred from the claim text.