Activated macrophage targetable drug carrier for treatment of atherosclerosis and methods of preparing the same
AssigneesKorea University Research and Business Foundation, Iucf-Hyu (Industry-University Cooperation Foundation Hanyang University), Korea Basic Science Institute
InventorsJin Won KIM, Hong Ki YOO, Kyeong Soon PARK
Life of this patent
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Abstract
Provided is a drug carrier for treatment of atherosclerosis including a biocompatible amphipathic polymer including a macrophage lignad polymer and a hydrophobic substance, and a hydrophobic drug.
Claims21
A drug carrier for treatment of atherosclerosis, the drug carrier comprising:
- a first amphipathic polymer including a macrophage ligand polymer and a hydrophobic substance;
- and
- a hydrophobic drug for treatment of atherosclerosis,
- wherein the macrophage ligand polymer is a dextran derivative, and the hydrophobic substance is a bile acid derivative.
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A drug carrier for treatment of atherosclerosis, the drug carrier comprising:
- a second amphipathic polymer including a hydrophilic polymer, a hydrophobic substance, and a target ligand recognizing a mannose receptor of a macrophage;
- and
- a hydrophobic drug for treatment of atherosclerosis,
- wherein the hydrophilic polymer is a chitosan derivative, and the hydrophobic substance is a cholesterol derivative.
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A drug carrier for treatment of atherosclerosis, the drug carrier comprising:
- a first amphipathic polymer including a macrophage ligand polymer and a hydrophobic substance;
- a second amphipathic polymer including a hydrophilic polymer, a hydrophobic substance, and a target ligand recognizing a mannose receptor of a macrophage;
- and
- a hydrophobic drug for treatment of atherosclerosis,
- wherein the macrophage ligand polymer is a dextran derivative,
- the hydrophobic substance is a cholesterol derivative, and
- the hydrophilic polymer is a chitosan derivative.
A drug carrier for treatment of atherosclerosis, the drug carrier comprising:
- a third amphipathic polymer including a macrophage ligand polymer, a hydrophobic substance, and a target ligand recognizing a mannose receptor of a macrophage;
- a second amphipathic polymer including a hydrophilic polymer, a hydrophobic substance, and a target ligand recognizing a mannose receptor of a macrophage;
- and
- a hydrophobic drug for treatment of atherosclerosis,
- wherein the macrophage ligand polymer is a dextran derivative,
- the hydrophobic substance is a cholesterol derivative, and
- the hydrophilic polymer is a chitosan derivative.
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A method of preparing a drug carrier for treatment of atherosclerosis, the method comprising:
- preparing an amphipathic polymer;
- forming nanoparticles by self-assembling the amphipathic polymer;
- and
- impregnating a hydrophobic drug in the nanoparticles.
A method of preparing a drug carrier for treatment of atherosclerosis, the method comprising:
- preparing an amphipathic polymer;
- forming nanoparticles by mixing the amphipathic polymer and a hydrophobic synthetic polymer;
- and
- impregnating a hydrophobic drug in the nanoparticles.
Dependencies are inferred from the claim text.