Yeast vaccine vector including immunostimulatory and antigenic polypeptides and methods of using the same
AssigneesBoard of Trustees of the University of Arkansas, The Texas A&M University System
InventorsOlivia B. Faulkner, Lisa Bielke, Leona Nicole Calhoun, Luc Berghman, Billy Hargis
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Abstract
Vaccine compositions including a yeast comprising an immunostimulatory polypeptide and optionally an antigenic polypeptide are provided herein. The immunostimulatory polypeptide and the antigenic polypeptide are expressed or displayed on the surface of the yeast vaccine composition. Methods of using the vaccine composition to vaccinate subjects are also provided.
Claims28
A yeast vaccine composition comprising a yeast comprising an immunostimulatory polynucleotide encoding an HMGB1 polypeptide or a CD40 ligand, wherein the yeast expresses the HMGB1 polypeptide or the CD40 ligand on the surface of the yeast.
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Dependencies are inferred from the claim text.