Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
OwnerStephen A. Berry, Pamela J. Fereira +2inventors
InventorsStephen A. Berry, Pamela J. Fereira, Houdin Dehnad, Anna Muchnik
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Abstract
This invention relates to stable non-aqueous single phase viscous vehicles and to formulations utilizing such vehicles. The formulations comprise at least one beneficial agent uniformly suspended in the vehicle. The formulation is capable of being stored at temperatures ranging from cold to body temperature for long periods of time. The formulations are capable of being uniformly delivered from drug delivery systems at an exit shear rate of between about 1 to 1×107 reciprocal second.
Claims13
A non-aqueous formulation comprising a beneficial agent, polymer, and sugar;
- suspended in a non-aqueous single-phase vehicle, wherein:
- the beneficial agent is glucagon-like peptide-1 (GLP-1) or a peptide analog thereof;
- the polymer comprises at least one of polylactic acid or polylacticpolyglycolic acid;
- and
- the non-aqueous single-phase vehicle comprises sesame oil, peanut oil or Miglyol® triglycerides.
A non-aqueous formulation comprising a beneficial agent and polymer;
- suspended in a non-aqueous single-phase vehicle, wherein:
- the beneficial agent is glucagon-like peptide-1 (GLP-1) or a peptide analog thereof;
- the polymer comprises at least one of polylactic acid or polylacticpolyglycolic acid;
- and
- the non-aqueous single-phase vehicle comprises sesame oil, peanut oil or Miglyol® triglycerides.
Dependencies are inferred from the claim text.