Osteocalcin as a treatment for frailty associated with aging
AssigneeThe Trustees of Columbia University in the City of New York
InventorsGerard KARSENTY, Paula MERA, Emilio ARTEAGA-SOLIS
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Abstract
Methods and compositions for treating frailty in mammals, preferably humans, are provided. The methods generally involve modulation of the OST-PTP signaling pathway or the PTP-1B signaling pathway involving gamma-carboxylase and osteocalcin, e.g., by administration of undercarboxylated/uncarboxylated osteocalcin. The methods comprise alleviating at least one of: muscle wasting or a lung disorder while also alleviating at least one of: a metabolic disorder, a male reproductive disorder, or a cognitive disorder.
Claims22
A method of treating frailty comprising administering to a patient suffering from frailty a pharmaceutical composition comprising a therapeutically effective amount of undercarboxylated/uncarboxylated osteocalcin and a pharmaceutically acceptable carrier or excipient.
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