Method of treating mucus hypersecretion
AssigneeParanta Biosciences Limited
InventorsRobyn O'Hehir, Charles Hardy, David De Kretser
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Abstract
The present invention relates generally to a method of reducing unwanted airway tissue mucus secretion in a mammal and to agents useful for same. More particularly, the present invention relates to a method of reducing airway tissue mucus hypersecretion in a mammal by downregulating the functional level of activin or upregulating the functional level of follistatin. The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterised by airway tissue mucus dysfunction, such as overproduction of mucus or decreased mucus clearance, and where a reduction in mucus secretion levels would thereby alleviate the condition.
Claims27
A method of reducing airway tissue mucus secretion in a mammal, said method comprising downregulating the functional level of activin or upregulating the functional level of follistatin in said mammal.
A method of therapeutically or prophylactically treating a condition which is characterised by airway tissue mucus dysfunction, said method comprising downregulating the functional level of activin or upregulating the functional level of follistatin in said mammal wherein downregulating said level of activin or upregulating said follistatin reduces airway tissue mucus secretion.
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Dependencies are inferred from the claim text.