Lipoprotein targeting protease inhibitors and uses
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Serv
InventorsAlan T. Remaley, Scott M. Gordon
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Abstract
Described herein is the design and construction of a class of lipoprotein targeting protease inhibitors. Small peptides with protease inhibitor activity are conjugated to hydrophobic, lipoprotein targeting molecules using, for instance, amine reactive chemistry. Methods of use of the resultant lipoprotein targeting protease inhibitor (antiprotease) molecules are also described. Also described is the production and use of protease inhibitor enriched HDL particles, as well as A1AT-peptide-enriched HDL particles, and their use in various therapeutic contexts.
Claims18
A lipoprotein targeting protease inhibitor peptide having the following generic structure:
- T-I
- in which T is a hydrophobic entity comprising a vitamin E (VitE), an acyl chain, or cholesterol;
- and
- I is a peptide-based protease inhibitor;
- where T is covalently attached directly to I, or indirectly by way of a hydrophilic linker L.
Dependencies are inferred from the claim text.