Phage therapy
AssigneePherecydes Pharma
InventorsFLAVIE POUILLOT, HELENE BLOIS
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Abstract
The present invention relates to bacteriophage therapy. More particularly, the present invention relates to novel bacteriophages having a high specificity against Pseudomonas aeruginosa strains, their manufacture, components thereof, compositions comprising the same and the uses thereof in phage therapy.
Claims18
1-20. (canceled)
An antibacterial composition comprising at least two bacteriophages having lytic activity against a Pseudomonas aeruginosa (P. aeruginosa) strain, said at least two bacteriophages selected from the bacteriophages having a genome comprising a nucleotide sequence of any one of SEQ ID NOs:
- 1 to 7 or a sequence having at least 90% identity thereto.
A method for preparing a composition comprising separately producing said at least two bacteriophages selected from the bacteriophages having a genome comprising a nucleotide sequence of any one of SEQ ID NOs:
- 1 to 7 or a sequence having at least 90% identity thereto, and combining said bacteriophages with a suitable carrier or excipient.
A method for treating an infection in a mammal, comprising exposing the mammal to:
- a) a bacteriophage having lytic activity to a Pseudomonas aeruginosa (P. aeruginosa) strain and having a genome comprising a nucleotide sequence selected from any one of SEQ ID NOs:
- 2 to 7 or a sequence having at least 95% identity thereto;
- b) isolated nucleic acid comprising a nucleotide sequence selected from any one of SEQ ID NOs:
- 2 to 7 or a sequence having at least 95% identity thereto;
- or
- c) isolated polypeptide encoded by a bacteriophage having lytic activity to a Pseudomonas aeruginosa (P. aeruginosa) strain and having a genome comprising a nucleotide sequence selected from any one of SEQ ID NOs:
- 2 to 7 or a sequence having at least 95% identity thereto or a polypeptide encoded by an isolated nucleic acid comprising a nucleotide sequence selected from any one of SEQ ID NOs:
- 2 to 7 or a sequence having at least 95% identity thereto.
Dependencies are inferred from the claim text.