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AssigneeBiovotec AS
InventorsRALF SCHMIDT, HENRI-PIERRE SUSO, ENDA KENNY
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The invention provides a particle consisting essentially of micronized ESM and having a mean particle diameter of less than 100 μm for use in promoting the healing of a chronic wound at risk of, or in which there is, (i) an inappropriate level of matrix-metalloproteinase (MMP) activity against extracellular matrix (ECM) proteins and/or peptide growth or differentiation factors, and/or (ii) an excessive inflammatory response. The invention further provides pharmaceutical compositions, wound dressings and implantable medical devices comprising the micronized ESM-containing particles for use in said treatments. The invention still further provides methods for manufacturing the micronized ESM-containing particles and the compositions, dressings and implantable medical devices comprising the same.
A method of promoting the healing of a chronic wound, comprising applying to the chronic wound a particle consisting essentially of micronized egg shell membrane (ESM) having a mean particle diameter of less than 100 μm, wherein the chronic wound is at risk of or has
The method of 11, wherein said microorganism is selected from the genera Citrobacter, Enterobacter, Escherichia, Hafnia, Serratia, Yersinia, Peptostreptococcus, Bacteroides, Pseudomonas, Legionella, Staphylococcus, Enterococcus, Streptococcus, Klebsiella, Candida, Proteus, Burkholderia, Fusobacterium or Mycobacterium, preferably wherein the microorganism is Escherichia coli, Enterococcus faecalis Staphylococcus aureus, Staphylococcus epidermidis, Legionella pneumophila, Candida albicans, Pseudomonas aeruginosa, Burkholderia cepacia or Streptococcus pyogenes.
21-26. (canceled)
Dependencies are inferred from the claim text.