Osteoinductive fibrous bone chips
AssigneeWarsaw Orthopedic, Inc.
InventorGuobao Wei
Life of this patent
Estimating the term…
Abstract
An osteoinductive composition is provided which includes a plurality of surface demineralized fibrous bone chips. Each fibrous bone chip has a BET surface area from about 10 m2/gm to about 70 m2/gm. The osteoinductive composition can also include fully demineralized bone fibers. The osteoinductive composition including the surface demineralized fibrous bone chips with or without fully demineralized bone fibers can be placed in a covering, such as a mesh bag. The osteoinductive composition can include other bone structures and/or bioactive agents and/or ceramics. A method of treating a bone cavity in a patient in need thereof with the osteoinductive composition including a plurality of surface demineralized fibrous bone chips with or without fully demineralized bone fibers is also provided.
Claims21
An osteoinductive composition, the osteoinductive composition comprising a plurality of pressure treated surface demineralized fibrous bone chips, each pressure treated surface demineralized fibrous bone chip having a mineral non-demineralized core and a demineralized surface layer and having a BET surface area from about 10 m2/gm to about 70 m2/gm, wherein the pressure treated surface demineralized fibrous bone chips are obtained by subjecting the surface demineralized bone chips to pressures from about 5,000 to about 10,000 psi and the pressure treated surface demineralized fibrous bone chip has a size that is about 25% to about 100% greater than the size of a demineralized bone chip.
(canceled)
(canceled)
An osteoinductive composition comprising a combination of pressure treated surface demineralized fibrous bone chips and fully demineralized bone fibers, each pressure treated surface demineralized fibrous bone chip having a BET surface area from about 10 m2/gm to about 35 m2/gm, wherein the pressure treated surface demineralized fibrous bone chips are obtained by subjecting the surface demineralized bone chips to pressures from about 5,000 to about 10,000 psi, and the pressure treated surface demineralized fibrous bone chip has a size that is about 25% to about 100% greater than the size of a demineralized bone chip, and the pressure treated surface demineralized fibrous bone chips and the fully demineralized fibers are in a ratio of from about 90:10 to about 10:90 W/W.
(canceled)
A method of treating a bone cavity in a patient in need thereof, the method comprising implanting in the bone cavity of the patient an osteoinductive composition comprising a plurality of surface demineralized fibrous bone chips, each surface demineralized fibrous bone chip having a BET surface area from about 10 m2/gm to about 70 m2/gm.
Dependencies are inferred from the claim text.