Stable neural stem cells comprising an exogenous polynucleotide coding for a growth factor and methods of use thereof
AssigneeNeuralstem, Inc.
InventorsThomas Hazel, Karl K. Johe
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Abstract
The present disclosure provides a human neural stem cell comprising an exogenous polynucleotide coding for a growth factor such as IGF-1. Also disclosed are methods of using the human neural stem cells for the treatment of neurodegenerative diseases or disorders including, for example, ALS.
Claims6
A stable human neural stem cell comprising a vector containing an exogenous polynucleotide coding for an insulin-like growth factor 1 (IGF-1) wherein the human neural stem cell is expandable for more than sixty cell doublings without undergoing differentiation.
A human neural stem cell comprising an exogenous polynucleotide coding for a growth factor.
Dependencies are inferred from the claim text.