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US 2017/0319620 A1Published application
Tumor lysate loaded particles
AssigneeOrbis Health Solutions LLC
InventorThomas E. Wagner
Life of this patent
Estimating the term…
Abstract
Dendritic cells containing tumor lysate loaded particles are prepared. The dendritic cells present tumor antigens to elicit the Major Histocompatibility Complex class I pathway and can be used as a vaccine to treat cancer, including ocular melanoma.
Claims15
A composition comprising a yeast cell wall particle and a tumor lysate loaded within the yeast cell wall particle, wherein about 200 μg to about 500 μg tumor lysate is present in about 109 yeast cell wall particles.
A method for producing a vaccine composition comprising:
- (i) loading the tumor lysate into the particle to produce the tumor lysate loaded particle;
- (ii) freeze-drying the tumor lysate loaded particle.
Dependencies are inferred from the claim text.