Immunosuppressive blood cells and methods of producing the same
AssigneeUniversitatsklinikum Heidelberg
InventorsPeter TERNESS, Gerhard OPELZ, Helmut SIMON, Sandra EHSER, Christian KLEIST, Flavius SANDRA-PETRESCU, Mircea IANCU, Lucian JIGA, Jing-Jing CHUANG, Thilo OELERT
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Abstract
The present invention refers to a method of producing immunosuppressive bleed cells that can be used for the treatment of autoimmune diseases, in particular multiple sclerosis, organ graft rejection and graft-versus-host disease.
Claims16
1-15. (canceled)
A method for treating an autoimmune disease, organ graft rejection, or graft-versus-host disease in a patient, said method comprising
- a) obtaining a blood cell sample and, optionally, preparing Peripheral Blood Mononuclear Cells (PBMCs) from said blood cell sample;
- b) treating said blood cell sample or PBMCs derived therefrom with a chemotherapeutic agent;
- and
- c) administering the treated blood cells or PBMCs of b) to said patient;
- and, thereby, treating an autoimmune disease, organ graft rejection, or graft-versus-host disease.
A method for treating an autoimmune disease, organ graft rejection, or graft-versus-host disease in a patient, said method comprising administering to the patient a composition comprising
- a) isolated blood cells treated with a therapeutically effective amount of a chemotherapeutic agent and optionally an autoantigen or a derivative thereof, and
- b) optionally, a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.