US 2017/0319614 A1Published application

Antisense-oligonucleotides as inhibitors of tgf-r signaling

AssigneeNeuroVision Pharma GmbH

InventorsMarkus HOSSBACH, Monika KRAMPERT, Hans-Lothar ARTH

Life of this patent

Estimating the term…

Abstract

The present invention relates to antisense-oligonucleotides having a length of at least 10 nucleotides, wherein at least two of the nucleotides are LNAs, their use as inhibitors of TGF-R signaling, pharmaceutical compositions containing such antisense-oligonucleotides and the use for prophylaxis and treatment of neurological, neurodegenerative, fibrotic and hyperproliferative diseases.

Claims14

Dependent claims

Antisense-oligonucleotide consisting of 10 to 28 nucleotides and at least two of the 10 to 28 nucleotides are LNAs and the antisense-oligonucleotide is capable of hybridizing with a region of the gene encoding the TGF-RII or with a region of the mRNA encoding the TGF-RII, wherein the region of the gene encoding the TGF-R1f or the region of the mRNA encoding the TGF-RII comprises the sequence TGGTCCATTC (Seq. ID No. 4) or the sequence CCCTAAACAC (Seq. ID No. 5) or the sequence ACTACCAAAT (Seq. ID No. 6) or the sequence GGACGCGTAT (Seq. ID No. 7) or the sequence GTCTATGACG (Seq. ID No. 8) or the sequence TTATTAATGC (Seq. ID No. 9), and the antisense-oligonucleotide comprises a sequence capable of hybridizing with said sequence TGGTCCATTC (Seq. ID No. 4) or sequence CCCTAAACAC (Seq. ID No. 5) or sequence ACTACCAAAT (Seq. ID No. 6) or sequence GGACGCGTAT (Seq. ID No. 7) or sequence GTCTATGACG (Seq. ID No. 8) or sequence TTATTAATGC (Seq. ID No. 9) respectively and salts and optical isomers of said antisense-oligonucleotide.

Antisense-oligonucleotide selected from the following group:

Seq ID No.
Sequence, 5′-3′
219a
Gb1sAb1sdAsdTsdGsdGsdAsdCsC*b1sAb1
219b
Gb1Ab1dAdTdGdGdAdCC*b1Ab1
220a
Tb1sGb1sAb1sdAsdTsdGsdGsdAsdCsC*b1sAb1sGb1
220b
Tb1Gb1Ab1dAdTdGdGdAdCC*b1Ab1Gb1
220c
Tb1sGb1sAb1sdAsdTsdGsdGsdAsdCsdC*sAb1sGb1
220d
Tb1sdGsdA*sdAsdTsdGsdGsdAsdC*sdCsAb1sGb1
220e
Tb1sGb1sdA*sdA*sdTsdGsdGsdA*sdC*sdC*sdAsGb1
221a
Tb1sGb1sAb1sAb1sdTsdGsdGsdAsdCsdCsAb1sGb1sTb1
221b
Tb1Gb1Ab1Ab1dUdGdGdAdCdCAb1Gb1Tb1
221c
Tb1sGb1sAb1sAb1sdTsdGsdGsdAsdCsdC*sAb1sGb1sTb1
221d
Tb1sGb1sAb1sdAsdTsdGsdGsdA*sdCsdC*sdAsGb1sTb1
221e
Tb1sGb1sdA*sdAsdTsdGsdGsdAsdC*sdCsdAsdGsTb1
221f
Tb1sdGsdAsdA*sdTsdGsdGsdAsdCsC*b1sAb1sGb1sTb1
222a
Ab1sTb1sGb1sAb1sdAsdTsdGsdGsdAsdCsC*b1sAb1sGb1sTb1
222b
Ab1Tb1Gb1Ab1dAsdTsdGsdGsdAsdCsdC*sAb1Gb1Tb1
222c
Ab1Tb1dGdA*dAdTdGdGdA*dCC*b1Ab1Gb1Tb1
222d
Ab4sTb4sGb4sdA*sdAsdTsdGsdGsdAsdCsdC*sAbsGb4sTb4
222e
Ab1sdTsdGsdA*sdA*sdTsdGsdGsdA*sdC*sdC*sdA*sdGsTb1
222f
Ab2sTb2sGb2sdA*sdAsdUsdGsdGsdAsdCsdCsAb2sGb2sTb2
222g
Ab4ssTb4ssdGssdAssdAssdTssdGssdGssdAssdCssdCssAb4ssGb4ssTb4
223a
Ab1sTb1sGb1sAb1sdAdTdGdGdAdCdC*sAb1sGb1sTb1sAb1
223b
Ab1ssTb1ssdGssdAssdAssdTssdGssdGssdAssdCssdCssdAssdGssdTssAb1
223c
Ab1dTdGdAdAdTdGdGdAdCdCdAdGdTAb1
223d
Ab1sTb1sdGsdAsdAsdUsdGsdGsdA*sdCsdCsdAsGb1sTb1sAb1
223e
Ab6Tb6Gb6dA*dAdTdGdGdAdCdC*dAGb6Tb6Ab6
223f
Ab1Tb1dGsdAsdAsdTsdGsdGsdAsdC*sdC*sAb1Gb1Tb1Ab1
223g
Ab4sTb4sGb4sdAsdAsdTsdGsdGsdAsdCsdCsdAsdGsTb4sAb4
223h
Ab1sTb1sGb1sAb1sdAsdTsdGsdGsdAsdC*sdC*sdAsdGsdTsAb1
223i
Ab1ssTb1ssdGssdAssdAssdUssdGssdGssdA*ssdCssdCssdAssdGssTb1ssAb1
218y
C*b2sAb2sTb2sdGsdAsdAsdTsdGsdGsdAsdCsdCsAb2sGb2sTb2sAb2
218z
C*b1sAb1sTb1sdGsdAsdAsdTsdGsdGsdAsdC*sdC*sAb1sGb1sTb1sAb1
218aa
C*b1ssAb1ssTb1ssdGssdAssdAssdTssdGssdGssdAssdCssdCssAb1ssGb1ss Tb1ssAb1
218ab
C*b1Ab1Tb1dGsdAsdAsdUsdGsdGsdAsdC*sdC*sAb1Gb1Tb1Ab1
218ac
C*b1Ab1Tb1dGsdA*sdA*sdTsdGsdGsdA*sdCsdCsAb1Gb1Tb1Ab1
218ad
C*b6sAb6sTb6sdGdAdAdTdGdGdAdCdCAb6sGb6sTb6sAb6
218ae
C*b7sAb7sTb7sGb7sdAsdAsdTsdGsdGsdAsdCsdCsdAsGb7sTb7sAb7
218af
C*bs1Ab1sdUsdGsdAsdAsdUsdGsdGsdUsdCsdCsAb1sGb1sTb1sAb1
218b
C*b1sAb1sTb1sdGsdAsdAsdTsdGsdGsdAsdCsdCsAb1sGb1sTb1sAb1
218m
C*b1sAb1sTb1sdGsdAsdAsdTsdGsdGsdAsdC*sdC*sAb1sGb1sTb1sAb1
218n
C*b1Ab1Tb1dGsdAsdAsdTsdGsdGsdAsdC*sdC*sAb1Gb1Tb1Ab1
218o
C*b1sAb1sTb1sdGsdA*sdA*sdTsdGsdGsdA*sdCsdCsAb1sGb1sTb1sAb1
218p
C*b1sAb1sTb1sdGsdA*sdA*sdTsdGsdGsdA*sdC*sdC*sAb1sGb1sTb1sAb1
218q
C*b1sAb1sTb1sdGsdAsdAsdTsdGsdGsdAsdC*sdCsAb1sGb1sTb1sAb1
218c
C*b1sAb1sTb1sdGsdAsdAsdTsdGsdGsdAsdCsdC*sAb1sGb1sTb1sAb1
218r
C*b1Ab1Tb1dGdAdAdTdGdGdAdCdCAb1Gb1Tb1Ab1
218s
C*b1sAb1sTb1sdGdAdAdTdGdGdAdC*sdC*sAb1sGb1sTb1sAb1
218t
/5SpC3s/C*b1sAb1sTb1sdGsdAsdAsdTsdGsdGsdAsdCsdCsAb1sGb1sTb1sAb1
218u
C*b1sAb1sTb1sdGsdAsdAsdTsdGsdGsdAsdCsdCsAb1sGb1sTb1sAb1/3SpC3s/
218v
/5SpC3s/C*b1sAb1sTb1sdGsdAsdAsdTsdGsdGsdAsdCsdCsAb1sGb1sTb1sAb1
/3SpC3s/
218ag
C*b1sAb1sTb1sdGsdA*sdA*sdUsdGsdGsdA*sdCsdCsAb1sGb1sTb1sAb1
218ah
C*b4ssAb4ssTb4ssdGssdA*ssdA*ssdTssdGssdGssdA*ssdCssdCssdAssdGss
Tb4ssAb4
218ai
C*b2ssAb2ssTb2ssGb2ssdAssdAssdTssdGssdGssdAssdCssdCssdAssdGssdT ssAb2
218aj
C*b1Ab1Tb1Gb1dAdAdUdGdGdAdCdCAb1Gb1Tb1Ab1
218ak
C*b1sAb1sTb1sGb1sAb1sdA*sdUsdGsdGsdAsdCsdCsdA*sGb1sTb1sAb1
218am
C*b1sAb1sdUsdGsdAsdAsdUsdGsdGsdAsdCsC*b1sAb1sGb1sTb1sAb1
218an
C*b6sAb6sTb6sGb6sdAsdAsdTsdGsdGsdAsdCsdCsdAsGb6sTb6sAb6
218ao
C*b7sAb7sTb7sdGsdA*sdA*sdUsdGsdGsdAsdCsdCsdA*sGb7sTb7sAb7
218ap
C*b4sAb4sTb4sGb4sdA*sdAsdTsdGsdGsdAsdCsdC*sdAsdGsTb4sAb4
218aq
C*b4Ab4Tb4Gb4dAdAdTdGdGdAdCdCdAdGTb4Ab4
218ar
C*b1sAb1sTb1sdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsGb1sTb1sAb1
224a
C*b1sAb1sTb1sGb1sAb1sdAsdTsdGsdGsdAsdCsdCsAb1sGb1sTb1sAb1sTb1
224b
C*b2sAb2sTb2sdGsdAsdAsdTsdGsdGsdAsdCsdCsAb2sGb2sTb2sAb2sTb2
224c
C*b1sAb1sTb1sGb1sdAsdAsdTsdGsdGsdAsdCsdCsdAsdGsTb1sAb1sTb1
224d
C*b1sdAsdUsdGsdAsdAsdUsdGsdGsdAsdC*sdC*sAb1sGb1sTb1sAb1sTb1
224e
C*b1sAb1sTb1sdGsdA*sdA*sdTsdGsdGsdA*sdC*sdC*sAb1sGb1sTb1sAb1sTb1
224f
C*b1Ab1dTdGdAdAdTdGdGdAdCdCdAGb1Tb1Ab1Tb1
224g
C*b1sdAsdTsdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsdGsTb1sAb1sTb1
224h
C*b1Ab1Tb1Gb1Ab1dA*dTdGdGdA*dC*dC*dAdGdTAb1Tb1
224i
C*b1ssAb1ssTb1ssGb1ssAb1ssdAssdTssdGssdGssdAssdCssdCssdAssdGss
Tb1ssAb1ssTb1
224j
C*b4Ab4Tb4dGdA*dA*dTdGdGdA*dCdCdAGb4Tb4Ab4Tb4
224k
C*b6sAb6sTb6sdGsdA*sdA*sdUsdGsdGsdA*sdC*sdC*sdAsdGsTb6sAb6sTb6
224m
C*b7sAb7sTb7sGb7sdAdAdTdGdGdAdC*dC*dAsGb7sTb7sAb7sTb7
225a
Tb1sC*b1sAb1sTb1sGb1sdAsdAsdTsdGsdGsdAsdCsdCsAb1sGb1sTb1sAb1sTb1
225b
Tb7sC*b7sAb7sTb7sGb7sdAsdAsdTsdGsdGsdAsdCsdCsdAsdGsdTsdAsTb7
225c
Tb1sC*b1sAb1sTb1sdGsdAsdAsdTsdGsdGsdAsdC*sdC*sdAsGb1sTb1sAb1sTb1
225d
Tb1sC*b1sAb1sdTsdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsGb1sTb1sAb1sTb1
225e
Tb1sC*b1sAb1sTb1sdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsdGsTb1sAb1sTb1
225f
Tb1C*b1dA*dTdGdAdAdUdGdGdAdCdC*Ab1Gb1Tb1Ab1Tb1
225g
Tb4C*b4Ab4Tb4sdGsdAsdAsdTsdGsdGsdAsdCsdCsAb4Gb4Tb4Ab4Tb4
225h
Tb1ssC*b1ssAb1ssdTssdGssdA*ssdA*ssdTssdGssdGssdAssdCssdC*ssdA*ss
dGssTb1ssAb1ssTb1
225i
Tb2C*b2Ab2dTdGdAdAdTdGdGdAdC*dC*Ab2Gb2Tb2Ab2Tb2
226a
Tb1sC*b1sAb1sTb1sGb1sdAsdAsdTsdGsdGsdAsdCsdCsdAsGb1sTb1sAb1sTb1sTb1
226b
Tb6C*b6Ab6Tb6Gb6dAdAdTdGdGdAdCdCdAGb6Tb6Ab6Tb6Tb6
226c
Tb1sC*b1sAb1sTb1sdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsdGsdTsAb1sTb1sTb1
226d
Tb1sdCsdAsdTsdGsdAsdA*sdUsdGsdGsdAsdCsdCsdAsGb1sTb1sAb1sTb1sTb1
226e
Tb4sC*b4sdAsdUsdGsdAsdAsdUsdGsdGsdAsdCsdC*sdAsdGsTb4sAb4sTb4sTb4
226f
Tb2ssC*b2ssAb2ssTb2ssGb2ssdAssdAssdTssdGssdGssdAssdCssdCssdAssdGssdTssd
AssTb2ssTb2
227a
C*b1sTb1sC*b1sAb1sTb1sdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsGb1sTb1sAb1
sTb1sTb1
227b
C*b2sTb2sC*b2sdAsdTsdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsGb2sTb2sAb2
sTb2sTb2
227c
C*b1Tb1C*b1dAdTdGdAdAdTdGdGdAdCdC*dAdGTb1Ab1Tb1Tb1
227d
C*b1sdUsdCsdAsdTsdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsGb1sTb1sAb1sTb1sTb1
227e
C*b4sTb4sC*b4sAb4sdTsdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsdGsTb4sAb4
sTb4sTb4
228a
Tb1sC*b1sTb1sC*b1sAb1sdTsdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsdGsTb1
sAb1sTb1sTb1sC*b1
228b
Tb1C*b1Tb1C*b1Ab1dTdGdAdAdTdGdGdAdC*dC*dAdGTb1Ab1Tb1Tb1C*b1
228c
Tb6sC*b6sTb6sdCsdAsdTsdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsdGsdTsAb6
sTb6sTb6sC*b6
229a
Ab1sTb1sC*b1sTb1sC*b1sdAsdTsdGsdAsdAsdTsdGsdGsdAsdC*sdCsdAsdGsdTsAb1
sTb1sTb1sC*b1sTb1
229b
Ab1Tb1C*b1Tb1C*b1AdTdGdAdAdTdGdGdAdCdCdAdGdTAb1Tb1Tb1C*b1Tb1
230a
Tb1sAb1sTb1sC*b1sTb1sdCsdAsdTsdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsdGsdTsd
AsTb1sTb1sC*b1sTb1sAb1
230a
Tb1sAb1sTb1sC*b1sTb1sdCsdAsdTsdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsdGsdTsd
AsTb1sTb1sC*b1sTb1sAb1
230b
Tb1Ab1Tb1C*b1Tb1dCdAdTdGdAdAdTdGdGdAdCdCdAdGdTdATb1Tb1C*b1Tb1
Ab1
231a
Ab1sTb1sAb1sTb1sC*b1sdTsdCsdAsdTsdGsdAsdAsdTsdGsdGsdAsdCsdCsdAsdGsd
TsdAsdTsTb1sC*b1sTb1sAb1sGb1
231b
Ab1Tb1Ab1Tb1C*b1dTdCdAdTdGdAdAdTdGdGdAdCdCdAdGdTdAdTTb1C*b1
Tb1Ab1Gb1
232a
C*b1sGb1sdTsdC*sdAsdTsdAsdGsAb1sC*b1
232b
C*b1Gb1dTdC*dAdTdAdGAb1C*b1
233a
Tb1sC*b1sGb1sdTsdC*sdAsdTsdAsdGsAb1sC*b1sC*b1
233b
Tb1C*b1Gb1dTdC*dAdTdAdGAb1C*b1C*b1
233c
Tb1sC*b1sGb1sdTsdC*sdAsdTsdAsdGsdAsC*b1sC*b1
233d
Tb1sdC*sdGsdTsdC*sdAsdTsdAsdGsdAsC*b1sC*b1
233e
Tb1sC*b1sdGsdTsdCsdAsdTsdAsdGsdAsdC*sC*b1
234a
Tb1sC*b1sGb1sTb1sdCsdAsdTsdAsdGsdAsC*b1sC*b1sGb1
234b
Tb1C*b1Gb1Tb1dCdAdUdAdGdAC*b1C*b1Gb1
234c
Tb1sC*b1sGb1sTb1sdC*sdAsdTsdAsdGsdAsC*b1sC*b1sGb1
234d
Tb1sC*b1sGb1sdTsdC*sdA*sdTsdA*sdGsdA*sdC*sC*b1sGb1
234e
Tb1sC*b1sdGsdTsdC*sdAsdTsdA*sdGsdA*sdC*sdCsGb1
234f
Tb1sdCsdGsdTsdC*sdA*sdTsdAsdGsAb1sC*b1sC*b1sGb1
142c
C*b1sGb1sTb1sdCsdAsdTsdAsdGsdAsdCsdCsGb1sAb1
143i
C*b1sTb1sC*b1sGb1sdTsdCsdAsdTsdAsdGsAb1sC*b1sC*b1sGb1
143j
C*b4ssTb4ssC*b4ssdGssdTssdCssdAssdTssdAssdGssdA*ssC*b4ssC*b4ssGb4
143h
C*b1sTb1sdCsdGsdTsdCsdAsdTsdAsdGsdAsC*b1sC*b1sGb1
143k
C*b2ssTb2ssC*b2ssdGssdTssdCssdAssdTssdAssdGssdAssC*b2ssC*b2ssGb2
143m
C*b1Tb1C*b1Gb1dUsdCsdAsdTsdAsdGsAb1C*b1C*b1Gb1
143n
C*b1sTb1sC*b1sGb1sTb1sdCsdA*sdTsdA*sdGsdA*sC*b1sC*b1sGb1
143o
C*b1sTb1sdCsdGsdUsdCsdAsdUsdAsGb1sAb1sC*b1sC*b1sGb1
143p
C*b6sTb6sC*b6sGb6sdTsdCsdAsdTsdAsdGsdAsC*b6sC*b6sGb6
143q
C*b7sTb7sC*b7sdGsdUsdCsdA*sdUsdA*sdGsdA*sC*b7sC*b7sGb7
143r
C*b4sTb4sC*b4sGb4sdTsdC*sdA*sdTsdAsdGsdAsdC*sC*b4sGb4
143s
C*b4Tb4C*b4Gb4dTdCdAdTdAdGdAdCC*b4Gb4
143t
C*b1ssTb1ssC*b1ssdGssdTssdC*ssdAssdTssdAssdGssdAssC*b1ssC*b1ssGb1
143u
C*b1Tb1sdCsdGsdUsdC*sdAsdUsdAsdGsdAsC*b1C*b1Gb1
143v
C*b1Tb1sdC*sdGsdTsdC*sdA*sdTsdAsdGsdAsC*b1C*b1Gb1
143w
C*b6sTb6sdC*dGdTdC*dAdTdAdGdAsC*b6sC*b6sGb6
143x
C*b7sTb7sC*b7sGb7sdTsdC*sdAsdTsdAsdGsdAsC*b7sC*b7sGb7
143y
C*b7sTb7sdC*sdGsdTsdCsdAsdUsdAsdGsAb7sC*b7sC*b7sGb7
143z
C*b1sTb1sdC*sdGsdTsdC*sdAsdTsdAsdGsdAsC*b1sC*b1sGb1
143aa
C*b1Tb1sdC*sdGsdTsdC*sdAsdTsdAsdGsdAsC*b1C*b1Gb1
143ab
C*b1sTb1sdC*sdGsdTsdC*sdA*sdTsdAsdGsdA*sC*b1sC*b1sGb1
143ac
C*b1sTb1sdC*sdGsdTsdCsdAsdTsdAsdGsdAsC*b1sC*b1sGb1
143ad
C*b1Tb1dC*dGdTdCdAdTdAdGdAC*b1C*b1Gb1
143ae
C*b1sTb1sdC*dGdTdC*dAdTdAdGdAsC*b1sC*b1sGb1
143af
/5SpC3s/C*b1sTb1sdC*dGdTdC*dA*dTdAdGdA*sC*b1sC*b1sGb1
143ag
C*b1sTb1sdC*dGdTdC*dA*dTdAdGdA*sC*b1sC*b1sGb1/3SpC3s/
143ah
/5SpC3s/C*b1sTb1sdC*dGdTdC*dA*dTdAdGdA*sC*b1sC*b1sGb1/3SpC3s/
143ai
C*b1sTb1sdC*sdGsdUsdC*sdA*sdUsdA*sdGsdA*sC*b1sC*b1sGb1
143aj
C*b1sTb1sC*b1sdGsdTsdCsdAsdTsdAsdGsdAsC*b1sC*b1sGb1
145c
Gb1sC*b1sTb1sdCsdGsdTsdCsdAsdTsdAsdGsAb1sC*b1sC*b1
235i
C*b1sTb1sC*b1sGb1sdTdC*dAdTdAdGdAsC*b1sC*b1sGb1sAb1
235a
C*b1ssTb1ssdCssdGssdTssdCssdAssdTssdAssdGssdAssdCssdCssdGssAb1
235b
C*b1Tb1dCdGdTdCdAdTdAdGdAdCdCdGAb1
235c
C*b1sTb1sdCsdGsdTsdCsdA*sdUsdAsdGsdAsdCsC*b1sGb1sAb1
235d
C*b1Tb1sdCsdGsdTsdCsdAsdTsdAsdGsdAsC*b1C*b1Gb1Ab1
235e
C*b4sTb4sC*b4sdGsdTsdCsdAsdTsdAsdGsdAsdCsdCsGb4sAb4
235f
C*b6sTb6sC*b6sdGdTdCdA*dTdAdGdAdC*sC*b6sGb6sAb6
235g
C*b1sTb1sC*b1sGb1sdTsdC*sdAsdTsdAsdGsdAsdC*sdC*sdGsAb1
235h
C*b1ssTb1ssdCssdGssdUssdCssdAssdUssdAssdGssdAssdCssdCssGb1 ssAb1
144c
Gb1sC*b1sTb1sdCsdGsdTsdCsdAsdTsdAsdGsdAsC*b1sC*b1sGb1
141c
Gb1sC*b1sTb1sC*b1sdGsdTsdC*sdAsdTsdAsdGsdAsC*b1sC*b1sGb1sAb1
141d
Gb1C*b1Tb1C*b1sdGsdTsdC*sdAsdTsdAsdGsdAsdCsC*b1Gb1Ab1
141e
Gb4sC*b4sTb4sC*b4sdGsdTsdC*sdAsdTsdAsdGsdA*sdC*sdC*sGb4sAb4
141f
Gb1sdC*sdTsdCsdGsdTsdC*sdA*sdTsdAsdGsdA*sdC*sdC*sdGsAb1
141g
Gb2sC*b2sTb2sdCsdGsdUsdCsdAsdTsdA*sdGsdAsdCsC*b2sGb2sAb2
141h
Gb4ssC*b4ssTb4ssdCssdGssdTssdCssdAssdTssdAssdGssdAssC*b4ssC*b4ssGb
4ssAb4
141i
Gb1C*b1dTdCdGdTdCdA*dTdA*dGdA*dCC*b1Gb1Ab1
141j
Gb1sC*b1sTb1sdCsdGsdTsdCsdAsdTsdAsdGsdAsdCsC*b1sGb1sAb1
139c
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237a
Tb1sGb1sC*b1sTb1sC*b1sdGsdTsdC*sdAsdTsdAsdGsAb1sC*b1sC*b1sGb1
sAb1
237b
Tb2sGb2sC*b2sdTsdGsdTsdC*sdAsdTsdAsdGsAb2sC*b2sC*b2sGb2sAb2
237c
Tb1sGb1sC*b1sTb1sdC*sdGsdTsdCsdAsdTsdAsdGsdAsdC*sC*b1sGb1sAb1
237d
Tb1sdGsdCsdUsdC*sdGsdTsdC*sdAsdUsdAsdGsAb1sC*b1sC*b1sGb1sAb1
237e
Tb1sGb1sC*b1sdTsdGsdTsdC*sdA*sdTsdA*sdGsAb1sC*b1sC*b1sGb1sAb1
237f
Tb1Gb1dC*dTdGdTdC*dAdTdAdGdAC*b1C*b1Gb1Ab1
237g
Tb1sdGsdC*sdTsdGsdTsdC*sdAsdTsdAsdGsdAsdC*sC*b1sGb1sAb1
237h
Tb1Gb1C*b1Tb1C*b1dGdTdC*dA*dTdA*dGdA*dC*dC*Gb1Ab1
237i
Tb1ssGb1ssC*b1ssTb1ssC*b1ssdGssdTssdCssdAssdTssdAssdGssdAssdC
ssC*b1ssGb1ssAb1
237j
Tb4sGb4sC*b4sdTdGdTdCdA*dTdA*dGdA*sC*b4sC*b4sGb4sAb4
237k
Tb6sGb6sC*b6sdUsdGsdUsdC*sdA*sdUsdA*sdGsdA*sdC*sC*b6sGb6sAb6
237m
Tb7sGb7sC*b7sTb7sdC*dGdTdC*dAdTdAdGdAsC*b7sC*b7sGb7sAb7
238a
Tb1sGb1sC*b1sTb1sC*b1sdGsdTsdC*sdAsdTsdAsdGsdAsC*b1sC*b1sGb1
sAb1sGb1
238b
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sGb7
238c
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b1
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238e
Tb1sGb1sC*b1sTb1sdC*sdGsdTsdCsdAsdTsdAsdGsdAsdC*sdC*sGb1sAb1
sGb1
238f
Tb1Gb1dC*dUdC*dGdTdC*dAdTdAdGdA*C*b1C*b1Gb1Ab1Gb1
238g
Tb4Gb4C*b4Tb4sdCsdGsdTsdCsdAsdTsdAsdGsdAsC*b4C*b4Gb4Ab4Gb4
238h
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ssdC*ssGb1ssAb1ssGb1
238i
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239a
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sAb1sGb1sC*b1
239b
Tb6Gb6C*b6Tb6C*b6dGdTdC*dAdTdAdGdAdC*C*b6Gb6Ab6Gb6C*b6
239c
Tb1sGb1sC*b1sTb1sdC*sdGsdTsdCsdAsdTsdAsdGsdAsdCsdCsdGsAb1
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239e
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ssdCssdGssdAssGb2ssC*b2
240a
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240b
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sAb2sGb2sC*b2
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240d
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sAb1sGb1sC*b1
240e
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242a
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242b
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dCsdC*sdGsdAsGb1sC*b1sC*b1sC*b1sC*b1
243b
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G C*b1C*b1C*b1C*b1C*b1
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246a
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246b
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246c
Ab1sTb1sAb1sdCsdGsdCsdGsdTsdC*sdC*sAb1sC*b1
246d
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Ab1sdTsdA*sdC*sdGsdC*sdGsdTsdC*sdC*sAb1sC*b1
247a
Gb1sAb1sTb1sAb1sdCsdGsdCsdGsdTsdCsC*b1sAb1sC*b1
247b
Gb1Ab1Tb1Ab1dCdGdCdGdUdCC*b1Ab1C*b1
247c
Gb1sAb1sTb1sAb1sdC*sdGsdCsdGsdTsdC*sC*b1sAb1sC*b1
247d
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247e
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248a
Gb1sAb1sTb1sAb1sdC*sdGsdC*sdGsdTsdC*sC*b1sAb1sC*b1sAb1
248b
Gb1Ab1Tb1Ab1sdC*sdGsdCsdGsdTsdC*sdC*sAb1C*b1Ab1
248c
Gb4sAb4sTb4sAb4sdC*sdGsdCsdGsdTsdC*sdC*sdA*sC*b4sAb4
248d
Gb1sdA*sdTsdAsdCsdGsdCsdGsdTsdCsdC*sdA*sdCsAb1
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Gb2sAb2sTb2sdA*sdCsdGsdCsdGsdUsdCsdCsAb2sC*b2sAb2
248f
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248g
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152h
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C*b1Gb1Ab1Tb1sdAsdCsdGsdCsdGsdUsdCsdC*sAb1C*b1Ab1
152j
C*b1Gb1Ab1Tb1sdA*sdCsdGsdCsdGsdUsdCsdCsAb1C*b1Ab1
152k
C*b6sGb6sAb6sTb6sdAdC*dGdCdGdTdCdC*sAb6sC*b6sAb6
152m
C*b1sGb1sAb1sTb1sdAsdCsdGsdCsdGsdTsdC*sdC*sAb1sC*b1sAb1
152n
C*b1Gb1Ab1Tb1sdAsdC*sdGsdC*sdGsdTsdC*sdC*sAb1C*b1Ab1
152o
C*b1sGb1sAb1sTb1sdA*sdCsdGsdCsdGsdTsdCsdC*sAb1sC*b1sAb1
152p
C*b1sGb1sAb1sTb1sdAsdCsdGsdCsdGsdTsdCsdC*sAb1sC*b1sAb1
152q
C*b1Gb1Ab1Tb1dAdCdGdC*dGdTdCdC*Ab1C*b1Ab1
152r
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152s
/5SpC3s/C*b1sGb1sAb1sTb1sdAsdC*sdGsdC*sdGsdTsdCsdCsAb1sC*b1 sAb1
152t
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152u
/5SpC3s/C*b1sGb1sAb1sTb1sdAsdC*sdGsdC*sdGsdTsdCsdCsAb1sC*b1
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152v
C*b1sGb1sAb1sTb1sdA*sdC*sdGsdC*sdGsdUsdC*sdC*sAb1sC*b1sAb1
152w
C*b7sGb7sAb7sdTsdAsdCsdGsdC*sdGsdTsdCsC*b7sAb7sC*b7sAb7
152z
C*b7sGb7sdAsdUsdAsdCsdGsdC*sdGsdUsdCsC*b7sAb7sC*b7sAb7
152aa
C*b1ssGb1ssAb1ssdTssdAssdC*ssdGssdCssdGssdTssdCssdC*ssAb1
ssC*b1ssAb1
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C*b4ssGb4ssAb4ssdTssdA*ssdCssdGssdCssdGssdTssdCssdCssdA*ss
C*b4ssAb4
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C*b2ssGb2ssAb2ssTb2ssdAssdCssdGssdCssdGssdTssdCssdCssdAssdCssAb2
152ad
C*b1Gb1Ab1Tb1dAdCdGdCdGdUdCC*b1Ab1C*b1Ab1
152ae
C*b1sGb1sAb1sTb1sAb1sdCsdGsdCsdGsdUsdCsdCsAb1sC*b1sAb1
152af
C*b1sGb1sdA*sdTsdA*sdCsdGsdCsdGsdTsC*b1sC*b1sAb1sC*b1sAb1
152ag
C*b6sGb6sAb6sdTsdAsdCsdGsdCsdGsdTsdCsC*b6sAb6sC*b6sAb6
152ah
C*b7sGb7sAb7sdUsdA*sdCsdGsdCsdGsdUsdCsdCsAb7sC*b7sAb7
152ai
C*b4sGb4sAb4sTb4sdA*sdCsdGsdCsdGsdTsdC*sdC*sdA*sC*b4sAb4
152aj
C*b4Gb4Ab4Tb4dAdCdGdCdGdTdCdCdAC*b4Ab4
152ak
C*b1sGb1sAb1sdTsdAsdCsdGsdCsdGsdTsdCsdCsAb1sC*b1sAb1
249a
C*b1sGb1sAb1sTb1sdAdCdGdCdGdTdCdC*sAb1sC*b1sAb1sGb1
249b
C*b1ssGb1ssdAssdTssdAssdCssdGssdCssdGssdTssdCssdCssdAssdCssdAssGb1
249c
C*b1Gb1dAdTdAdCdGdCdGdTdCdCdAdCdAGb1
249d
C*b1sGb1sdAsdUsdAsdC*sdGsdCsdGsdUsdCsdC*sdAsC*b1sAb1sGb1
249e
C*b1Gb1sdAsdTsdAsdC*sdGsdC*sdGsdTsdCsdC*sAb1C*b1Ab1Gb1
249f
C*b4sGb4sAb4sdTsdAsdCsdGsdCsdGsdTsdCsdCsdAsdCsAb4sGb4
249g
C*b6Gb6Ab6dTdA*dCdGdCdGdTdC*dCdA*C*b6Ab6Gb6
249h
C*b1sGb1sAb1sTb1sdAsdC*sdGsdCsdGsdTsdCsdC*sdAsdC*sdAsGb1
249i
C*b1ssGb1ssdAssdUssdAssdCssdGssdCssdGssdUssdCssdCssdAssdCss
Ab1ssGb1
250a
Gb1sC*b1sGb1sAb1sTb1sdAsdCsdGsdC*sdGsdTsdCsC*b1sAb1sC*b1sAb1
sGb1
250b
Gb1sC*b1sGb1sAb1sdTsdAsdC*sdGsdC*sdGsdTsdC*sdC*sdAsC*b1sAb1
sGb1
250c
Gb1sdC*sdGsdAsdUsdAsdCsdGsdC*sdGsdUsdCsC*b1sAb1sC*b1sAb1sGb1
250d
Gb1sC*b1sGb1sdA*sdTsdA*sdC*sdGsdC*sdGsdTsdC*sC*b1sAb1sC*b1sAb1
sGb1
250e
Gb1C*b1dGdAdTdAdCdGdC*dGdTdCdC*Ab1C*b1Ab1Gb1
250f
Gb1sdC*sdGsdAsdTsdAsdCsdGsdC*sdGsdTsdCsdCsdAsC*b1sAb1sGb1
250g
Gb2sC*b2sGb2sdAsdTsdAsdCsdGsdC*sdGsdTsdC*sC*b2sAb2sC*b2sAb2
sGb2
250h
Gb1C*b1Gb1Ab1Tb1dA*dCdGdC*dGdTdC*dCdA*dC*Ab1Gb1
250i
Gb1ssC*b1ssGb1ssAb1ssTb1ssdAssdCssdGssdCssdGssdTssdCssdCssdAssC*b1s
sAb1ssGb1
250j
Gb4sC*b4sGb4sdA*sdTsdA*sdCsdGsdCsdGsdTsdCsdCsAb4sC*b4sAb4sGb4
250k
Gb6sC*b6sGb6sdA*sdUsdAsdCsdGsdCsdGsdUsdC*sdCsdA*sC*b6sAb6sGb6
250m
Gb7sC*b7sGb7sAb7sdTdAdCdGdCdGdTdC*dCsAb7sC*b7sAb7sGb7
251a
Gb1sC*b1sGb1sAb1sTb1sdAsdCsdGsdCsdGsdTsdCsdC*sAb1sC*b1sAb1
sGb1sGb1
251b
Gb7sC*b7sGb7sAb7sTb7sdAsdC*sdGsdCsdGsdTsdCsdCsdAsdCsdAsdGs Gb7
251c
Gb1sC*b1sGb1sAb1sdTsdAsdC*sdGsdCsdGsdTsdCsdC*sdAsC*b1sAb1sGb1s
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Gb1sC*b1sGb1sdAsdTsdAsdC*sdGsdC*sdGsdTsdCsdC*sdAsC*b1sAb1sGb1s
Gb1
251e
Gb1sC*b1sGb1sAb1sdTsdAsdC*sdGsdCsdGsdTsdCsdC*sdAsdC*sAb1sGb1
sGb1
251f
Gb1C*b1dGdAdUdA*dCdGdCdGdTdC*dC*Ab1C*b1Ab1Gb1Gb1
251g
Gb4C*b4Gb4Ab4sdTsdAsdCsdGsdCsdGsdTsdCsdCsAb4C*b4Ab4Gb4Gb4
251h
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ssdC*ssAb1ssGb1ssGb1
251i
Gb2C*b2Gb2dAdTdAdCdGdC*dGdTdCdC*Ab2C*b2Ab2Gb2Gb2
252a
Gb1sC*b1sGb1sAb1sTb1sdAsdC*sdGsdCsdGsdTsdCsdCsdAsC*b1sAb1sGb1s
Gb1sAb1
252b
Gb6C*b6Gb6Ab6Tb6dAdC*dGdCdGdTdCdC*dAC*b6Ab6Gb6Gb6Ab6
252c
Gb1sC*b1sGb1sdAsdTsdAsdCsdGsdCsdGsdTsdCsdCsdAsdC*sAb1sGb1
sGb1sAb1
252d
Gb1sdC*sdGsdA*sdTsdA*sdC*sdGsdCsdGsdTsdCsdCsdA*sC*b1sAb1sGb1
sGb1sAb1
252e
Gb4sC*b4sdGsdAsdUsdAsdCsdGsdCsdGsdUsdCsdCsdAsdC*sAb4sGb4sGb4sA
b4
252f
Gb2ssC*b2ssGb2ssAb2ssTb2ssdAssdCssdGssdCssdGssdTssdCssdCssdAssdCssd
AssdGssGb2ssAb2
253a
Gb1sGb1sC*b1sGb1sAb1sdTsdAsdCsdGsdCsdGsdTsdC*sdC*sdAsC*b1sAb1s
Gb1sGb1sAb1
253b
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sGb2sGb2sAb2
253c
Gb1Gb1C*b1dGdAdTdAdCdGdCdGdTdCdCdAdC*Ab1Gb1Gb1Ab1
253d
Gb1sdGsdCsdGsdAsdTsdAsdCsdGsdC*sdGsdUsdCsdCsdAsC*b1sAb1sGb1
sGb1sAb1
253e
Gb4sGb4sC*b4sGb4sdAsdTsdAsdCsdGsdCsdGsdTsdCsdCsdAsdCsAb4sGb4sG
b4sAb4
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sGb1sGb1sAb1sC*b1
254b
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b1
254c
Tb6sGb6sGb6sC*b6sdGsdAsdTsdAsdCsdGsdCsdGsdTsdCsdCsdAsdCsdA
sdGsGb6sAb6sC*b6
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sdCsdAsGb1sGb1sAb1sC*b1sGb1
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1 C*b1Gb1
256a
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CsdAsdGsGb1sAb1sC*b1sGb1sAb1
256b
Gb1C*b1Tb1Gb1Gb1dC*dGdAdTdAdCdGdCdGdTdCdCdAdC*dAdGGb1Ab1
C*b1Gb1Ab1
257a
Tb1sGb1sC*b1sTb1sGb1sdGsdCsdGsdAsdTsdAsdC*sdGsdC*sdGsdTsdCsdCs
dAsdCsdAsdGsGb1sAb1sC*b1sGb1sAb1
257b
Tb1Gb1C*b1Tb1Gb1dGdCdGdAdTdAdCdGdCdGdTdCdC*dAdC*dAdGGb1
Ab1C*b1Gb1Ab1
258a
Gb1sTb1sdGsdTsdTsdTsdA*sdGsGb1sGb1
258b
Gb1sTb1sdGsdUsdTsdTsdA*sdGsGb1sGb1
259a
Ab1sGb1sTb1sdGsdTsdTsdTsdA*sdGsGb1sGb1sAb1
259b
Ab1Gb1Tb1dGdUdUdUdA*dGGb1Gb1Ab1
259c
Ab1sGb1sTb1sdGsdTsdTsdTsdA*sdGsdGsGb1sAb1
259d
Ab1sGb1sdTsdGsdTsdTsdTsdA*sdGsdGsdGsAb1
259e
Ab1sdGsdTsdGsdTsdTsdTsdA*sdGsdGsGb1sAb1
260a
Tb1sAb1sGb1sTb1sdGsdTsdTsdTsdAsdGsGb1sGb1sAb1
260b
Tb1Ab1Gb1Tb1dGdUdUdUdAdGGb1Gb1Ab1
260c
Tb1sAb1sGb1sTb1sdGsdTsdTsdTsdA*sdGsGb1sGb1sAb1
260d
Tb1sAb1sGb1sdUsdGsdTsdTsdTsdA*sdGsdGsGb1sAb1
260e
Tb1sAb1sdGsdUsdGsdUsdUsdUsdA*sdGsdGsdGsAb1
260f
Tb1sdA*sdGsdTsdGsdTsdTsdUsdA*sGb1sGb1sGb1sAb1
261a
Tb1sAb1sGb1sTb1sdGsdTsdTsdTsdA*sdGsGb1sGb1sAb1sGb1
261b
Tb1Ab1Gb1Tb1sdGsdTsdTsdTsdA*sdGsdGGb1Ab1Gb1
261c
Tb4sAb4sGb4sTb4sdGsdUsdTsdUsdA*sdGsdGsdGsAb4sGb4
261d
Tb1sdA*sdGsdUsdGsdTsdTsdUsdA*sdGsdGsdGsdA*sGb1
261e
Tb2sAb2sGb2sdUsdGsdUsdUsdTsdAsdGsdGsGb2sAb2sGb2
261f
Tb4sAb4sdGsdTsdGsdTsdTsdTsdAsdGsdGsGb4sAb4sGb4
261g
Tb1Ab1dGdTdGdTdTdTdA*dGGb1Gb1Ab1Gb1
262a
Tb1sAb1sGb1sTb1sdGdTdTdTdA*dGdGsGb1sAb1sGb1sC*b1
262b
Tb1ssAb1ssdGssdTssdGssdTssdTssdTssdAssdGssdGssdGssdAssdGssC*b1
262c
Tb1sAb1sdGsdUsdGsdUsdUsdUsdA*sdGsdGsdGsAb1sGb1sC*b1
262d
Tb1dAdGdTdGdTdTdTdAdGdGdGdAdGC*b1
262e
Tb1Ab1sdGsdUsdGsdUsdTsdUsdAsdGsdGsGb1Ab1Gb1C*b1
262f
Tb4sAb4sGb4sdTsdGsdTsdTsdTsdAsdGsdGsdsdGsdAsGb4sC*b4
262g
Tb6Ab6Gb6dUdGdTdTdUdAdGdGdGAb6Gb6C*b6
262h
Tb1sAb1sGb1sTb1sdGsdTsdTsdTsdAsdGsdGsdGsdAsdGsC*b1
262i
Tb1ssAb1ssdGssdTssdGssdUssdUssdUssdAssdGssdGssdGssdAssGb1 ssC*b1
209s
Gb1Tb1dAsdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsAb1Gb1C*b1
209t
Gb1sTb1sdA*sdGsdTsdGsdTsdTsdTsdA*sdGsdGsdGsAb1sGb1sC*b1
209u
Gb1Tb1dAdGdTdGdTdTdTdAdGdGdGAb1Gb1C*b1
209v
/5SpC3s/Gb1sTb1sdAsdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsAb1sGb1sC*b1
209w
Gb1sTb1sdAsdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsAb1sGb1sC*b1/s3SpC3/
209x
/5SpC3s/Gb1sTb1sdAsdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsAb1sGb1sC*b1/
3SpC3s/
209y
Gb1sTb1sdAsdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsAb1sGb1sC*b1
209aa
Gb1Tb1dA*sdGsdUsdGsdUsdUsdUsdAsdGsdGsdGsAb1Gb1C*b1
209ab
Gb1Tb1dA*sdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsAb1Gb1C*b1
209ac
Gb6sTb6sdA*dGdTdGdTdTdTdA*dGdGdGAb6sGb6sC*b6
209ad
Gb1sTb1sdA*sdGsdUsdGsdUsdUsdUsdA*sdGsdGsdGsAb1sGb1sC*b1
209ae
Gb1sTb1sdA*sdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsAb1sGb1sC*b1
209af
Gb1sTb1sdAsdGsdTsdGsdTsdTsdTsdA*sdGsdGsdGsAb1sGb1sC*b1
209ag
Gb1Tb1dA*dGdTdGdTdTdTdA*dGdGdGAb1Gb1C*b1
209ah
Gb1Tb1dAdGdTdGdTdTdTdA*dGdGdGAb1Gb1C*b1
209ai
Gb6sTb6sdA*dGdTdGdTdTdTdAdGdGdGAb6sGb6sC*b6
209aj
Gb1sTb1sdA*sdGsdUsdGsdTsdTsdUsdA*sdGsdGsdGsAb1sGb1sC*b1
209ak
Gb7sTb7sAb7sGb7sdTsdGsdTsdTsdTsdA*sdGsdGsdGsAb7sGb7sC*b7
209am
Gb7sTb7sdAsdGsdTsdGsdTsdTsdUsdA*sdGsdGsGb7sAb7sGb7sC*b7
209an
Gb1ssTb1ssAb1ssdGssdTssdGssdTssdTssdTssdA*ssdGssdGssdGssAb1
ssGb1ssC*b1
209ao
Gb4ssTb4ssAb4ssdGssdTssdGssdTssdTssdTssdAssdGssdGssdGssdA*ss
Gb4ssC*b4
209ap
Gb2ssTb2ssAb2ssGb2ssdTssdGssdTssdTssdTssdAssdGssdGssdGssdAssdGssC*
b2
209aq
Gb1Tb1Ab1Gb1dUdGdUdUdUdAdGdGGb1Ab1Gb1C*b1
209ar
Gb1sTb1sAb1sGb1sTb1sdGsdTsdTsdTsdA*sdGsdGsdGsAb1sGb1sC*b1
209as
Gb1sTb1sdAsdGsdTsdGsdTsdTsdUsdAsdGsGb1sGb1sAb1sGb1sC*b1
209at
Gb6sTb6sAb6sGb6sdTsdGsdTsdTsdTsdAsdGsdGsdGsAb6sGb6sC*b6
209au
Gb7sTb7sAb7sdGsdUsdGsdTsdTsdTsdA*sdGsdGsdGsAb7sGb7sC*b7
209av
Gb4sTb4sAb4sGb4sdUsdGsdTsdUsdTsdA*sdGsdGsdGsdA*sGb4sC*b4
209aw
Gb4Tb4Ab4Gb4dTdGdTdTdTdAdGdGdGdAGb4C*b4
209ax
Gb1sTb1sAb1sdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsAb1sGb1sC*b1
209az
Gb1sTb1sAb1sdGsdTsdGsdTsdTsdTsdAsdGsdGsGb1sAb1sGb1sC*b1
209ba
Gb1sTb1sAb1sGb1sdTsdGsdTsdTsdTsdAsdGsdGsGb1sAb1sGb1sC*b1
209bb
Gb1sTb1sAb1sdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsdAsGb1sC*b1
263a
Gb1sTb1sAb1sGb1sTb1sdGsdTsdTsdTsdA*sdGsdGsGb1sAb1sGb1sC*b1
sC*b1
263b
Gb2sTb2sAb2sdGsdTsdGsdTsdTsdTsdA*sdGsdGsGb2sAb2sGb2sC*b2sC*b2
263c
Gb1sTb1sAb1sGb1sdTsdGsdTsdTsdTsdA*sdGsdGsdGsAb1sGb1sC*b1sC*b1
263d
Gb1sdUsdA*sdGsdUsdGsdUsdTsdTsdA*sdGsdGsGb1sAb1sGb1sC*b1sC*b1
263e
Gb1sTb1sAb1sdGsdTsdGsdUsdTsdTsdA*sdGsdGsGb1sAb1sGb1sC*b1sC*b1
263f
Gb1Tb1dA*dGdTdGdTdTdTdA*dGdGdGAb1Gb1C*b1C*b1
263g
Gb1sdTsdA*sdGsdTsdGsdTsdTsdTsdA*sdGsdGsdGsdA*sGb1sC*b1sC*b1
263h
Gb1Tb1Ab1Gb1Tb1dGdTdUdTdAdGdGdGdA*dGC*b1C*b1
263i
Gb1ssTb1ssAb1ssGb1ssTb1ssdGssdTssdTssdTssdAssdGssdGssdGssdAssGb1ss
C*b1ssC*b1
263j
Gb4Tb4dA*dGdTdGdTdTdTdAdGdGdGdA*Gb4C*b4C*b4
263k
Gb6sTb6sAb6sdGsdTsdGsdUsdUsdTsdAsdGsdGsdGsdA*sGb6sC*b6sC*b6
263m
Gb7sTb7sAb7sGb7sdTdGdTdTdTdA*dGdGdGsAb7sGb7sC*b7sC*b7
264a
Gb1sGb1sTb1sAb1sGb1sdTsdGsdTsdTsdTsdA*sdGsdGsGb1sAb1sGb1sC*b1s
C*b1
264b
Gb7sGb7sTb7sAb7sGb7sdTsdGsdTsdTsdTsdAsdGsdGsdGsdAsdGsdC*sC*b7
264c
Gb1sGb1sTb1sAb1sGb1sdTsdGsdTsdTsdTsdAsdGsdGsdGsdA*sdGsdC*s C*b1
264d
Gb1sGb1sTb1sAb1sGb1sdUsdGsdTsdTsdTsdAsdGsdGsdGsdA*sdGsdC*s C*b1
264e
Gb1sGb1sTb1sAb1sdGsdTsdGsdTsdTsdTsdA*sdGsdGsdGsAb1sGb1sC*b1
sC*b1
264f
Gb1sGb1sTb1sdA*sdGsdTsdGsdTsdTsdTsdA*sdGsdGsdGsAb1sGb1sC*b1
sC*b1
264g
Gb1sGb1sTb1sAb1sdGsdTsdGsdTsdTsdTsdA*sdGsdGsdGsdA*sGb1sC*b1
sC*b1
264h
Gb1Gb1dUdA*dGdTdGdTdTdTdAdGdGGb1Ab1Gb1C*b1C*b1
264i
Gb4Gb4Tb4Ab4dGsdTsdGsdTsdTsdTsdAsdGsdGsGb4Ab4Gb4C*b4C*b4
264j
Gb1ssGb1ssTb1ssdA*ssdGssdTssdGssdUssdTssdTssdA*ssdGssdGssdGss
dA*ssGb1ssC*b1ssC*b1
264k
Gb2Gb2Tb2dA*dGdTdGdTdTdTdAdGdGGb2Ab2Gb2C*b2C*b2
265a
Gb1sGb1sTb1sAb1sGb1sdTsdGsdTsdTsdTsdA*sdGsdGsdGsAb1sGb1sC*b1
sC*b1sGb1
265b
Gb6Gb6Tb6Ab6Gb6dTdGdTdTdTdA*dGdGdGAb6Gb6C*b6C*b6Gb6
265c
Gb1sGb1sTb1sAb1sdGsdTsdGsdTsdTsdTsdA*sdGsdGsdGsdA*sdGsC*b1
sC*b1sGb1
265d
Gb1sdGsdTsdA*sdGsdUsdGsdTsdUsdTsdA*sdGsdGsdGsAb1sGb1sC*b1
sC*b1sGb1
265e
Gb4sGb4sdUsdAsdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsdA*sGb4sC*b4sC*b4s
Gb4
265f
Gb2ssGb2ssTb2ssAb2ssGb2ssdTssdGssdTssdTssdTssdAssdGssdGssdGssdAssd
GssdCssC*b2ssGb2
266a
Tb1sGb1sGb1sTb1sAb1sdGsdTsdGsdTsdTsdTsdA*sdGsdGsdGsAb1sGb1
sC*b1sC*b1sGb1
266b
Tb2sGb2sGb2sdTsdA*sdGsdTsdGsdTsdTsdTsdA*sdGsdGsdGsAb2sGb2
sC*b2sC*b2sGb2
266c
Gb1Gb1Tb1dA*dGdTdGdTdTdTdA*dGdGdGdA*Gb1C*b1C*b1Gb1
266d
Tb1sdGsdGsdUsdA*sdGsdTsdGsdTsdUsdTsdA*sdGsdGsdGsAb1sGb1sC*b1sC
*b1sGb1
266e
Tb4sGb4sGb4sTb4sdAsdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsdAsGb4sC*b4
sC*b4sGb4
267a
Tb1sTb1sGb1sGb1sTb1sdAsdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsdA*sGb1
sC*b1sC*b1sGb1sTb1
267b
Tb1Tb1Gb1Gb1Tb1dA*dGdTdGdTdTdTdAdGdGdGdA*Gb1C*b1C*b1Gb1T
b1
267c
Tb6sTb6sGb6sdGsdTsdAsdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsdAsGb6
sC*b6sC*b6sGb6sTb6
268a
Tb1sTb1sTb1sGb1sGb1sdTsdA*sdGsdTsdGsdTsdTsdTsdAsdGsdGsdGsdA
sdGC*b1sC*b1sGb1sTb1sC*b1
268b
Tb1Tb1Tb1Gb1Gb1dTdA*dGdTdGdTdTdTdAdGdGdGdA*dGC*b1C*b1Gb1
Tb1 C*b1
269a
Ab1sTb1sTb1sTb1sGb1sdGsdTsdAsdGsdTsdGsdTsdTsdTsdAsdGsdGsdG
sdAsdGsdC*sC*b1sGb1sTb1sC*b1sTb1
269b
Ab1Tb1Tb1Tb1Gb1dGdTdAdGdTdGdTdTdTdAdGdGdGdAdGdC*C*b1Gb1T
b1 C*b1Tb1
270a
Tb1sAb1sTb1sTb1sTb1sdGsdGsdTsdAsdGsdTsdGsdTsdTsdTsdAsdGsdG
sdGsdAsdGsdC*sdCsGb1sTb1sC*b1sTb1sTb1
270b
Tb1Ab1Tb1Tb1Tb1dGdGdTdAdGdTdGdTdTdTdAdGdGdGdAdGdC*dC*Gb1
Tb1C*b1Tb1Tb1
271a
Ab1sTb1sdTsdTsdGsdGsdTsdA*sGb1sTb1
271b
Ab1Tb1dTdTdGdGdTdA*Gb1Tb1
272a
Tb1sAb1sTb1sdTsdTsdGsdGsdTsdA*sGb1sTb1sGb1
272b
Tb1Ab1Tb1dTdTdGdGdTdA*Gb1Tb1Gb1
272c
Tb1sAb1sTb1sdTsdTsdGsdGsdTsdA*sdGsTb1sGb1
272d
Tb1sAb1sdTsdTsdTsdGsdGsdTsdA*sdGsdUsGb1
272e
Tb1sdAsdTsdUsdTsdGsdGsdUsdA*sdGsTb1sGb1
273a
Tb1sAb1sTb1sdTsdTsdGsdGsdTsdAsGb1sTb1sGb1sTb1
273b
Tb1Ab1Tb1dUdUdGdGdUdAGb1Tb1Gb1Tb1
273c
Tb1sAb1sTb1sdTsdTsdGsdGsdTsdA*sGb1sTb1sGb1sTb1
273d
Tb1sAb1sTb1sdTsdTsdGsdGsdTsdA*sdGsdUsGb1sTb1
273e
Tb1sAb1sdUsdUsdUsdGsdGsdUsdA*sdGsdUsdGsTb1
273f
Tb1sdA*sdTsdTsdUsdGsdGsdTsdA*sGb1sTb1sGb1sTb1
274a
C*b1Tb1Ab1sdUsdTsdTsdGsdGsdTsdA*sGb1Tb1Gb1Tb1
274b
C*b4sTb4sAb4sTb4sdTsdTsdGsdGsdTsdA*sdGsdUsGb4sTb4
274c
C*b1sdUsdA*sdTsdTsdTsdGsdGsdTsdAsdGsdTsdGsTb1
274d
C*b2sTb2sAb2sdTsdTsdUsdGsdGsdTsdA*sdGsTb2sGb2sTb2
274e
C*b4ssTb4ssdAssdTssdTssdTssdGssdGssdTssdAssdGssTb4ssGb4ssTb4
274f
C*b1Tb1Ab1dTdTdTdGdGdTdA*Gb1Tb1Gb1Tb1
274g
C*b1sTb1sAb1sTb1sdTsdTsdGsdGsdTsdA*sGb1sTb1sGb1sTb1
275a
C*b1sTb1sAb1sTb1sdTsdTsdGsdGsdTsdA*sdGsdTsdGsdTsTb1
275b
C*b1sTb1sdA*sdUsdTsdUsdGsdGsdTsdAsdGsdUsGb1sTb1sTb1
275c
C*b4sTb4sAb4sdTsdTsdTsdGsdGsdTsdAsdGsdTsdGsTb4sTb4
275d
C*b1ssTb1ssdAssdTssdTssdTssdGssdGssdTssdAssdGssdTssdGssdTssTb1
275e
C*b1ssTb1ssdAssdUssdTssdTssdGssdGssdTssdAssdGssdUssdGssTb1ssTb1
275f
C*b1sTb1sAb1sTb1sdTdTdGdGdTdA*dGsTb1sGb1sTb1sTb1
275g
C*b1Tb1sdAsdTsdTsdTsdGsdGsdTsdA*sdGsTb1Gb1Tb1Tb1
275h
C*b6Tb6Ab6dUdTdTdGdGdTdA*dGdUGb6Tb6Tb6
275i
C*b1dTdAdTdTdTdGdGdTdAdGdTdGdTTb1
210o
Gb1C*b1Tb1Ab1dTsdTsdTsdGsdGsdTsdAsdGsdTsGb1Tb1Tb1
210p
Gb1sC*b1sTb1sAb1sdTsdTsdTsdGsdGsdTsdA*sdGsdTsGb1sTb1sTb1
210q
Gb1sC*b1sTb1sAb1sdTsdTsdTsdGsdGsdTsdAsdGsdTsGb1sTb1sTb1
210r
Gb1C*b1Tb1Ab1dTdTdTdGdGdTdA*dGdTGb1Tb1Tb1
210s
Gb1sC*b1sTb1sAb1sdUsdUsdTdGsdGsdTsdA*sdGsdTsGb1sTb1sTb1
210t
Gb1sC*b1sTb1sAb1sdUsdTsdTsdGsdGsdTsdAsdGsdUsGb1sTb1sTb1
210u
Gb1sC*b1sTb1sAb1sdUsdUsdUsdGsdGsdUsdA*sdGsdUsGb1sTb1sTb1
210v
/5SpC3s/Gb1sC*b1sTb1sAb1sdTsdTsdTsdGsdGsdTsdAsdGsdTsGb1sTb1sTb1
210w
Gb1sC*b1sTb1sAb1sdTsdTsdTsdGsdGsdTsdAsdGsdTsGb1sTb1sTb1/3SpC3s/
210x
/5SpC3s/Gb1sC*b1sTb1sAb1sdTsdTsdTsdGsdGsdTsdAsdGsdTsGb1sTb1
sTb1/3SpC3s/
210y
Gb1C*b1Tb1Ab1sdTsdTsdTsdGsdGsdTsdA*sdGsdTsGb1Tb1Tb1
210z
Gb1C*b1Tb1Ab1sdUsdTsdTsdGsdGsdUsdA*sdGsdTsGb1Tb1Tb1
210aa
Gb1sC*b1sTb1sAb1sdTdTdTdGdGdTdA*dGdTsGb1sTb1sTb1
210ab
Gb6sC*b6sTb6sAb6sdTdTdTdGdGdTdA*dGdTsGb6sTb6sTb6
210ac
Gb6sC*b6sTb6sdAsdTsdTsdTsdGsdGsdTsdAsdGsTb6sGb6sTb6sTb6
210ad
Gb7sC*b7sTb7sdA*sdTsdTsdTsdGsdGsdTsdA*sdGsTb7sGb7sTb7sTb7
210ae
Gb7sC*b7sdUsdAsdTsdTsdUsdGsdGsdUsdA*sdGsTb7sGb7sTb7sTb7
210af
Gb1ssC*b1ssTb1ssdAssdTssdTssdTssdGssdGssdTssdA*ssdGssdTssGb1
ssTb1ssTb1
210ag
Gb4ssC*b4ssTb4ssdA*ssdTssdTssdTssdGssdGssdTssdAssdGssdTssdGss
Tb4ssTb4
210ah
Gb2ssC*b2ssTb2ssAb2ssdTssdTssdTssdGssdGssdTssdAssdGssdTssdGss
dTssTb2
210ai
Gb1C*b1Tb1Ab1dUsdTsdTsdGsdGsdTsdAsdGsTb1Gb1Tb1Tb1
210aj
Gb4C*b4Tb4Ab4dTsdTsdTsdGsdGsdTsdAsdGsdTdGTb4Tb4
210ak
Gb1sC*b1sTb1sAb1sTb1sdTsdTsdGsdGsdTsdA*sdGsdTsGb1sTb1sTb1
210am
Gb4sC*b4sTb4sAb4sdTsdTsdUsdGsdGsdTsdA*sdGsdTsdGsTb4sTb4
210an
Gb7sC*b7sTb7sdA*sdTsdTsdUsdGsdGsdTsdA*sdGsdTsGb7sTb7sTb7
210ao
Gb1sC*b1sdUsdAsdUsdUsdTsdGsdGsdUsdAsGb1sTb1sGb1sTb1sTb1
210ap
Gb1sC*b1sTb1sdAsdTsdTsdTsdGsdGsdTsdAsdGsdTsGb1sTb1sTb1
210aq
Gb1sC*b1sTb1sdAsdTsdTsdTsdGsdGsdTsdAsdGsdTsdGsTb1sTb1
276a
Gb1sC*b1sTb1sAb1sTb1sdTsdTsdGsdGsdTsdA*sdGsTb1sGb1sTb1sTb1sTb1
276b
Gb2sC*b2sTb2sdAsdTsdTsdTsdGsdGsdTsdA*sdGsTb2sGb2sTb2sTb2sTb2
276c
Gb1sC*b1sTb1sdAsdTsdTsdTsdGsdGsdTsdA*sdGsdTsGb1sTb1sTb1sTb1
276d
Gb2sdC*sdTsdAsdTsdTsdTsdGsdGsdTsdAsdGsTb2sGb2sTb2sTb2sTb2
276e
Gb6sC*b6sTb6sdA*sdUsdUsdUsdGsdGsdUsdA*sdGsdUsdGsTb6sTb6sTb6
276f
Gb1sdC*sdTsdA*sdUsdUsdUsdGsdGsdUsdAsdGsdUsdGsTb1sTb1sTb1
276g
Gb1C*b1dTdA*dTdTdTdGdGdTdA*dGdTGb1Tb1Tb1Tb1
276h
Gb4C*b4Tb4Ab4dTdTdTdGdGdTdA*dGdTdGTb4Tb4Tb4
276i
Gb1C*b1Tb1Ab1Tb1dUdTdGdGdTdA*dGdTdGdUTb1Tb1
276j
Gb1ssC*b1ssTb1ssAb1ssTb1ssdTssdTssdGssdGssdTssdAssdGssdTssdGssTb1ss
Tb1ssTb1
276k
Gb7sC*b7sTb7sAb7sdTdTdTdGdGdTdA*dGdTsGb7sTb7sTb7sTb7
277a
Ab1sGb1sC*b1sTb1sAb1sdTsdTsdTsdGsdGsdTsdA*sdGsTb1sGb1sTb1sTb1
sTb1
277b
Ab7sGb7sC*b7sTb7sAb7sdTsdTsdTsdGsdGsdTsdA*sdGsdTsdGsdTsdTsTb7
277c
Ab1sGb1sdC*sdTsdAsdTsdTsdTsdGsdGsdTsdAsdGsTb1sGb1sTb1sTb1sTb1
277d
Ab1sGb1sdC*sdTsdAsdTsdTsdTsdGsdGsdTsdA*sdGsTb1sGb1sTb1sTb1sTb1
277e
Ab1Gb1dC*dTdAdUdTdTdGdGdTdA*dGTb1Gb1Tb1Tb1Tb1
277f
Ab2Gb2C*b2dTdAdTdTdTdGdGdTdA*dGTb2Gb2Tb2Tb2Tb2
277g
Ab1sGb1sC*b1sTb1sdA*sdTsdTsdTsdGsdGsdTsdA*sdGsdTsGb1sTb1sTb1
sTb1
277h
Ab1sGb1sC*b1sTb1sdA*sdTsdTsdTsdGsdGsdTsdAsdGsdTsdGsTb1sTb1sTb1
277i
Ab1sGb1sC*b1sdTsdA*sdTsdTsdTsdGsdGsdTsdA*sdGsdTsGb1sTb1sTb1
sTb1
277j
Ab4Gb4C*b4Tb4sdAsdTsdTsdTsdGsdGsdTsdAsdGsTb4Gb4Tb4Tb4Tb4
277k
Ab1ssGb1ssC*b1ssdTssdA*ssdTssdTssdTssdGssdGssdTssdA*ssdGssdUssdGssT
b1ssTb1ssTb1
278a
Ab1sGb1sC*b1sTb1sAb1sdTsdTsdTsdGsdGsdTsdA*sdGsdTsGb1sTb1sTb1
sTb1sAb1
278b
Ab2ssGb2ssC*b2ssTb2ssAb2ssdTssdTssdTssdGssdGssdTssdAssdGssdTssdGssd
TssdTssTb2ssAb2
278c
Ab1sdGsdC*sdTsdAsdTsdTsdTsdGsdGsdTsdA*sdGsdTsGb1sTb1sTb1sTb1
sAb1
278d
Ab1sdGsdC*sdTsdAsdTsdTsdTsdGsdGsdUsdA*sdGsdUsGb1sTb1sTb1sTb1
sAb1
278e
Ab1sGb1sC*b1sdTsdAsdTsdTsdTsdGsdGsdTsdA*sdGsdTsdGsTb1sTb1sTb1
sAb1
278f
Ab4sGb4sdC*sdTsdAsdTsdTsdTsdGsdGsdTsdAsdGsdTsdGsTb4sTb4sTb4
sAb4
278g
Ab6Gb6C*b6Tb6Ab6dTdTdTdGdGdTdA*dGdTGb6Tb6Tb6Tb6Ab6
279a
Gb1sAb1sGb1sC*b1sTb1sdAsdTsdTsdTsdGsdGsdTsdA*sdGsdTsGb1sTb1
sTb1sTb1sAb1
279b
Gb2sAb2sGb2sdC*sdTsdAsdTsdTsdTsdGsdGsdTsdAsdGsdTsGb2sTb2sTb2
sTb2sAb2
279c
Gb1sdAsdGsdC*sdUsdAsdTsdTsdTsdGsdGsdTsdA*sdGsdTsGb1sTb1sTb1
sTb1sAb1
279d
Gb4sAb4sGb4sC*b4sdTsdAsdTsdTsdTsdGsdGsdTsdAsdGsdTsdGsTb4sTb4
sTb4sAb4
279e
Gb1Ab1Gb1dC*dTdAdTdTdTdGdGdTdAdGdTdGTb1Tb1Tb1Ab1
280a
Ab1sGb1sAb1sGb1sC*b1sdTsdAsdTsdTsdTsdGsdGsdTsdAsdGsdTsdGsTb1
sTb1sTb1sAb1sGb1
280b
Ab1Gb1Ab1Gb1C*b1dTdAdTdTdTdGdGdTdAdGdTdGTb1Tb1Tb1Ab1Gb1
280c
Ab1sGb1sAb1sGb1sdC*sdTsdAsdTsdTsdTsdGsdGsdTsdAsdGsdTsdGsTb1
sTb1sTb1sAb1sGb1
280d
Ab6sGb6sAb6sGb6sdC*sdTsdAsdTsdTsdTsdGsdGsdTsdA*sdGsdTsdGsdTsdTs
Tb6sAb6sGb6
281a
Ab1sAb1sGb1sAb1sGb1sdC*sdTsdAsdTsdTsdTsdGsdGsdTsdAsdGsdTsdGsdT
sTb1sTb1sAb1sGb1sGb1
281b
Ab1Ab1Gb1Ab1Gb1dC*dTdAdTdTdTdGdGdTdAdGdTdGdTTb1Tb1Ab1Gb1
Gb1
282a
Gb1sAb1sAb1sGb1sAb1sdGsdC*sdTsdAsdTsdTsdTsdGsdGsdTsdAsdGsdTsdG
sdTsdTsTb1sAb1sGb1sGb1sGb1
282b
Gb1Ab1Ab1Gb1Ab1dGdC*dTdAdTdTdTdGdGdTdAdGdTdGdTdTTb1Ab1Gb
1Gb1Gb1
283a
Ab1sGb1sAb1sAb1sGb1sdAsdGsdC*sdTsdAsdTsdTsdTsdGsdGsdTsdAsdGsdT
sdGsdTsdTsdTsAb1sGb1sGb1sGb1sAb1
283b
Ab1Gb1Ab1Ab1Gb1dAdGdC*dTdAdTdTdTdGdGdTdAdGdTdGdTdTdTAb1
Gb1Gb1Gb1Ab1
284a
C*b1sAb1sdTsdTsdAsdAsdTsdA*sAb1sAb1
284b
C*b1Ab1dTdTdA*dAdTdA*Ab1Ab1
285a
Gb1sC*b1sAb1sdTsdTsdA*sdA*sdTsdAsAb1sAb1sGb1
285b
Gb1sC*b1sAb1sdTsdTsdA*sdA*sdTsdAsdA*sAb1sGb1
285c
Gb1sC*b1sdAsdTsdTsdA*sdA*sdUsdAsdA*sdA*sGb1
285d
Gb1sdC*sdAsdTsdTsdAsdAsdTsdAsdAsAb1sGb1
285e
Gb1sdC*sdAsdTsdTsdAsdAsdTsdAsdA*sAb1sGb1
285f
Gb1C*b1Ab1dTdTdA*dA*dTdAAb1Ab1Gb1
286a
Gb1sC*b1sAb1sTb1sdTsdAsdAsdTsdAsdAsAb1sGb1sTb1
286b
Gb1sC*b1sAb1sTb1sdTsdA*sdA*sdTsdAsdAsAb1sGb1sTb1
286c
Gb1sC*b1sAb1sdUsdTsdAsdAsdTsdAsdAsdA*sGb1sTb1
286d
Gb1sC*b1sdAsdTsdTsdAsdA*sdUsdAsdAsdAsdGsTb1
286e
Gb1sdC*sdAsdTsdTsdAsdAsdTsdAsAb1sAb1sGb1sTb1
286f
Gb1sdC*sdAsdTsdTsdAsdAsdTsdA*sAb1sAb1sGb1sTb1
286g
Gb1C*b1Ab1Tb1dUdAdAdUdAdAAb1Gb1Tb1
287a
Gb1sGb1sC*b1sAb1sdTsdTsdA*sdAsdTsdAsAb1sAb1sGb1sTb1
287b
Gb4sGb4sC*b4sAb4sdTsdTsdA*sdAsdUsdAsdAsdA*sGb4sTb4
287c
Gb1sdGsdCsdAsdUsdUsdAsdAsdTsdA*sdA*sdA*sdGsTb1
287d
Gb2sGb2sC*b2sdA*sdUsdTsdA*sdAsdTsdAsdA*sAb2sGb2sTb2
287e
Gb1Gb1C*b1Ab1sdTsdTsdAsdAsdTsdA*sdA*sAb1Gb1Tb1
287f
Gb1sGb1sdC*sdAsdTsdTsdAsdAsdTsdAsAb1sAb1sGb1sTb1
287g
Gb1sGb1sdC*sdA*sdTsdTsdA*sdA*sdTsdA*sAb1sAb1sGb1sTb1
287h
Gb1Gb1dC*dAdTdTdAdAdTdAAb1Ab1Gb1Tb1
287i
Gb4ssGb4ssdCssdAssdTssdTssdAssdAssdTssdAssAb4ssAb4ssGb4ssTb4
287j
Gb4ssGb4ssdC*ssdAssdTssdTssdAssdAssdTssdAssAb4ssAb4ssGb4ssTb4
288a
Gb1sGb1sdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsGb1sTb1sGb1
288b
Gb1sGb1sC*b1sAb1sdTsdTsdA*sdA*sdTsdAsdAsdAsdGsdTsGb1
288c
Gb4sGb4sC*b4sdAsdTsdTsdAsdAsdTsdAsdAsdAsdGsTb4sGb4
288d
Gb1sGb1sC*b1sAb1sdTdTdAdAdTdAdAsAb1sGb1sTb1sGb1
288e
Gb1Gb1sdC*sdAsdTsdTsdAsdAsdTsdAsdAsAb1Gb1Tb1Gb1
288f
Gb1ssGb1ssdCssdAssdUssdUssdAssdAssdUssdAssdAssdAssdGssTb1ssGb1
288g
Gb1ssGb1ssdCssdAssdTssdTssdAssdAssdTssdAssdAssdAssdGssdTssGb1
288h
Gb6Gb6C*b6dA*dTdTdAdAdUdA*dA*dAGb6Tb6Gb6
288i
Gb1Gb1C*b1dAdTdTdAdAdUdAdAdAGb1Tb1Gb1
289a
Ab1sGb1sGb1sC*b1sAb1sdTsdTsdA*sdA*sdTsdA*sAb1sAb1sGb1sTb1sGb1
289b
Ab1sGb1sGb1sdC*sdAsdTsdTsdAsdAsdTsdAsAb1sAb1sGb1sTb1sGb1
289c
Ab1sGb1sGb1sdC*sdA*sdTsdTsdA*sdA*sdTsdA*sAb1sAb1sGb1sTb1sGb1
289d
Ab2sGb2sGb2sdC*sdAsdTsdTsdAsdAsdTsdAsAb2sAb2sGb2sTb2sGb2
289e
Ab1sdGsdGsdC*sdAsdTsdTsdAsdAsdTsdAsAb1sAb1sGb1sTb1sGb1
289f
Ab1sdGsdGsdC*sdAsdTsdUsdAsdAsdUsdAsAb1sAb1sGb1sTb1sGb1
289g
Ab1sGb1sGb1sdC*sdAsdTsdTsdAsdAsdTsdAsdAsAb1sGb1sTb1sGb1
289h
Ab1sGb1sGb1sC*b1sdA*sdTsdTsdA*sdA*sdTsdA*sdAsdAsGb1sTb1sGb1
289i
Ab6sGb6sGb6sdC*sdA*sdUsdTsdAsdAsdTsdAsdAsdAsGb6sTb6sGb6
289j
Ab1sGb1sGb1sdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsGb1sTb1sGb1
289k
Ab1sdGsdGsdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsGb1sTb1sGb1
289m
Ab1Gb1Gb1C*b1Ab1dUdTdA*dA*dTdAdAdAdGTb1Gb1
289n
Ab1Gb1dGdC*dAdTdTdAdAdTdAdAAb1Gb1Tb1Gb1
289o
Ab4Gb4Gb4dCdA*dTdTdAdAdTdAdA*Ab4Gb4Tb4Gb4
289p
Ab1ssGb1ssGb1ssC*b1ssAb1ssdTssdTssdAssdAssdTssdAssdAssdAss
Gb1ssTb1ssGb1
289q
Ab7sGb7sGb7sC*b7sdA*dTdTdAdAdTdAdA*sAb7sGb7sTb7sGb7
213j
C*b1sAb1sGb1sdGsdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsGb1sTb1sGb1
213k
C*b1sAb1sGb1sdGsdCsdAsdTsdTsdAsdAsdTsdAsdAsdAsGb1sTb1sGb1
213m
C*b1sAb1sGb1sdGsdC*sdAsdTsdTsdAsdAsdTsdAsdA*sdA*sGb1sTb1sGb1
213n
C*b1Ab1Gb1dGdC*dAdTdTdAdAdTdAdAdAGb1Tb1Gb1
213o
/5SpC3s/C*b1sAb1sGb1sdGsdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsGb1sTb1s
Gb1
213p
C*b1sAb1sGb1sdGsdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsGb1sTb1sGb1
/3SpC3s/
213q
/5SpC3s/C*b1sAb1sGb1sdGsdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsGb1sTb1s
Gb1/3SpC3s/
213r
C*b1sAb1sGb1sdGsdC*sdAsdTsdTsdAsdAsdUsdAsdAsdA*sGb1sTb1sGb1
213s
C*b6sAb6sGb6sdGdC*dAdTdTdAdAdTdAdAdAsGb6sTb6sGb6
213t
C*b1sAb1sGb1sdGdC*dAdTdTdAdAdTdAdAdAsGb1sTb1sGb1
213u
C*b1Ab1Gb1sdGsdC*sdAsdUsdUsdAsdAsdUsdAsdAsdAsGb1Tb1Gb1
213v
C*b1Ab1Gb1sdGsdC*sdAsdTsdTsdAsdA*sdTsdAsdAsdA*sGb1Tb1Gb1
213w
C*b1Ab1Gb1sdGsdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsGb1Tb1Gb1
213x
C*b7sAb7sGb7sGb7sdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsGb7sTb7sGb7
213y
C*b6sAb6sGb6sGb6sdCsdAsdTsdTsdAsdAsdTsdAsdAsdAsGb6sTb6sGb6
213z
C*b7sAb7sGb7sdGsdCsdA*sdUsdTsdAsdAsdTsdAsdAsAb7sGb7sTb7sGb7
213aa
C*b4sAb4sGb4sGb4sdC*sdA*sdTsdTsdAsdAsdTsdAsdA*sdAsdGsTb4sGb4
213ab
C*b1sAb1sGb1sGb1sC*b1sdA*sdTsdTsdA*sdA*sdTsdAsdA*sdA*sGb1sTb1
sGb1
213ac
C*b1sAb1sGb1sdGsdCsdAsdTsdTsdA*sdA*sdTsdAsAb1sAb1sGb1sTb1sGb1
213ad
C*b1sAb1sdGsdGsdC*sdAsdTsdTsdAsdAsdUsdAsdAsAb1sGb1sTb1sGb1
213ae
C*b1ssAb1ssGb1ssdGssdC*ssdAssdTssdTssdAssdAssdTssdAssdAssAb1
ssGb1ssTb1ssGb1
213af
C*b4ssAb4ssGb4ssdGssdCssdAssdTssdTssdA*ssdAssdTssdAssdAssdAss
dGssTb4ssGb4
213ag
C*b2ssAb2ssGb2ssGb2ssdCssdAssdTssdTssdAssdAssdTssdAssdAssdAss
dGssdTssGb2
213ah
C*b1Ab1Gb1Gb1dCdAdTdTdAdAdUdAdAAb1Gb1Tb1Gb1
213ai
C*b4Ab4Gb4Gb4dCdAdTdTdAdAdTdAdAdAdGTb4Gb4
213aj
C*b1Ab1Gb1dGdCdAdTdTdAdAdUdAdAdAGb1Tb1Gb1
213ak
C*b1sAb1sGb1sGb1sdCsdAsdTsdTsdAsdAsdTsdAsdAsAb1sGb1sTb1sGb1
290a
C*b1sAb1sGb1sGb1sC*b1sdAsdTsdTsdAsdAsdTsdA*sdAsAb1sGb1sTb1sGb1s
C*b1
290b
C*b1sAb1sGb1sGb1sdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsGb1sTb1sGb1
sC*b1
290c
C*b1sAb1sGb1sGb1sdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsdGsTb1sGb1
sC*b1
290d
C*b1sAb1sGb1sdGsdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsGb1sTb1sGb1
sC*b1
290e
C*b7sAb7sGb7sGb7sC*b7sdA*sdTsdTsdAsdAsdTsdAsdAsdAsdGsdTsdG
sC*b7
290f
C*b4Ab4Gb4Gb4sdCsdAsdTsdTsdAsdAsdTsdA*sdAsAb4Gb4Tb4Gb4C*b4
290 g
C*b1ssAb1ssGb1ssdGssdC*ssdAssdTssdTssdA*ssdAssdTssdA*ssdAssdA*
ssdGssTb1ssGb1ssC*b1
290h
C*b2Ab2Gb2dGdC*dAdTdTdAdAdTdAdAAb2Gb2Tb2Gb2C*b2
290i
C*b1Ab1dGdGdC*dA*dUdUdAdAdUdA*dA*Ab1Gb1Tb1Gb1C*b1
291a
Ab1sC*b1sAb1sGb1sGb1sdC*sdAsdTsdTsdAsdAsdTsdAsdAsAb1sGb1sTb1
sGb1sC*b1
291b
Ab1sC*b1sAb1sGb1sdGsdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsdGsTb1sGb1s
C*b1
291c
Ab4sC*b4sdAsdGsdGsdC*sdAsdTsdTsdAsdAsdUsdAsdAsdAsGb4sTb4sGb4
sC*b4
291d
Ab1sdC*sdAsdGsdGsdC*sdA*sdTsdTsdAsdAsdTsdAsdAsAb1sGb1sTb1sGb1s
C*b1
291e
Ab2ssC*b2ssAb2ssGb2ssGb2ssdCssdAssdTssdTssdAssdAssdTssdAssdAssdAssd
GssdTssGb2ssC*b2
291f
Ab6C*b6Ab6Gb6Gb6dC*dAdTdTdAdAdTdAdAAb6Gb6Tb6Gb6C*b6
292a
Ab1sC*b1sAb1sGb1sGb1sdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsGb1sTb1
sGb1sC*b1sAb1
292b
Ab2sC*b2sAb2sdGsdGsdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsGb2sTb2sGb2s
C*b2sAb2
292c
Ab1sdC*sdAsdGsdGsdC*sdAsdUsdUsdAsdAsdUsdAsdAsdAsGb1sTb1sGb1
sC*b1sAb1
292d
Ab4sC*b4sAb4sGb4sdGsdCsdAsdTsdTsdAsdAsdTsdAsdAsdAsdGsTb4sGb4
sC*b4sAb4
292e
Ab1C*b1Ab1dGdGdC*dAdTdTdAdAdTdAdAdAdGTb1Gb1C*b1Ab1
293a
Tb1sAb1sC*b1sAb1sGb1sdGsdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsdGsTb1s
Gb1sC*b1sAb1sAb1
293b
Tb1Ab1C*b1Ab1Gb1dGdC*dAdTdTdAdAdTdAdAdAdGTb1Gb1C*b1Ab1Ab1
293c
Tb6sAb6sC*b6sdAsdGsdGsdCsdAsdTsdTsdAsdAsdTsdAsdAsdAsdGsTb6
sGb6sC*b6sAb6sAb6
294a
Ab1sTb1sAb1sC*b1sAb1sdGsdGsdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsdG
sdTsGb1sC*b1sAb1sAb1sAb1
294b
Ab1Tb1Ab1C*b1Ab1dGdGdC*dAdTdTdAdAdTdAdAdAdGdTGb1C*b1Ab1A
b1 Ab1
295a
Tb1sAb1sTb1sAb1sC*b1sdAsdGsdGsdC*sdAsdTsdTsdAsdAsdTsdAsdAsdAsd
GsdTsdGsC*b1sAb1sAb1sAb1sTb1
295b
Tb1Ab1Tb1Ab1C*b1dAdGdGdC*dAdTdTdAdAdTdAdAdAdGdTdGC*b1Ab1
Ab1Ab1Tb1
236a
Ab1sTb1sAb1sTb1sAb1sdC*sdAsdGsdGsdC*sdAsdTsdTsdAsdAsdTsdAsdAsdA
sdGsdTsdGsdC*sAb1sAb1sAb1sTb1sGb1
236b
Ab1Tb1Ab1Tb1Ab1dC*dAdGdGdCdAdTdTdAdAdTdAdAdAdGdTdGdC*Ab1
Ab1Ab1Tb1Gb1

1,391 more elements

Dependencies are inferred from the claim text.

Facts

Application: 15/525,561Filed 16 Nov 2015
Priority: EP 14193368.916 Nov 2014
Published: 9 Nov 2017
Term ends: Not estimatedThe source records don’t support an estimate.

Classification41 codes

A61K 31/7125
Compounds having three or more nucleosides or nucleotides: nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other…
A61P 1/04
Drugs for disorders of the alimentary tract or the digestive system: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of…
A61P 1/16
Drugs for disorders of the alimentary tract or the digestive system: for liver or gallbladder disorders, e.g. hepatoprotective agents,…
A61P 7/00
Drugs for disorders of the blood or the extracellular fluid

Family

US 11,213,541 B2Related patent
US 2017/0319614 A1This patent

From the US filing history. Foreign family members aren’t listed.

Timeline

Citations

Open elsewhere

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Abstract

Facts

Application

15/525,561Filed 16 Nov 2015

Priority

EP 14193368.916 Nov 2014

Published

9 Nov 2017

Term ends

Not estimatedThe source records don’t support an estimate.

Classification41 codes

A61K 31/7125
Compounds having three or more nucleosides or nucleotides: nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other…
A61P 1/04
Drugs for disorders of the alimentary tract or the digestive system: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of…
A61P 1/16
Drugs for disorders of the alimentary tract or the digestive system: for liver or gallbladder disorders, e.g. hepatoprotective agents,…
A61P 7/00
Drugs for disorders of the blood or the extracellular fluid