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US 2017/0319612 A9Published application
Inhibition of nonsense mediated mrna decay by drugs that prevent hypusination of eukaryotic initiation factor 5a
AssigneeRutgers, The State University of New Jersey
InventorsTsafi Pe'ery, Michael B. Mathews, Mainul Hoque, Hartmut M. Hanauske-Abel
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Abstract
Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD an inhibitor of NMD and a nonsense suppressor, whereby degradation of NMD susceptible mRNA is decreased and translation termination at a misplaced nonsense codon is blocked.
Claims26
A method for treating a NAD in a patient or controlling expression of NAD-causing proteins in a cell culture, the method comprising administering to the patient suffering from a NAD or treating the cell culture with:
- 1) an inhibitor of NMD;
- and
- 2) a nonsense suppressor;
- whereby degradation of NMD-susceptible mRNA is decreased and translation termination at a misplaced nonsense codon is blocked.
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Dependencies are inferred from the claim text.