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US 2017/0319610 A1Published application
Means and methods for treatment of early-onset parkinson's disease
AssigneesVib Vzw, Katholieke Universiteit Leuven, KU Leuven R&E
InventorsPatrik Verstreken, Vanessa Morais Epifânio, Melissa Vos
Life of this patent
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Abstract
This application relates to the field of neurodegenerative diseases, more particularly to the field of Parkinson's disease. In particular, the disclosure describes that inhibitors reducing FAS activity can be used for treatment of Parkinson's disease, in particular, the treatment of patients suffering from Parkinson's disease having loss of function mutations in PINK1 or PARKIN genes.
Claims12
A method of treating a subject with early-onset Parkinson's disease, the method comprising:
- administering to the subject a fatty acid synthase (FAS) inhibitor (FAS inhibitor) so as to treat the subject's early-onset Parkinson's disease,
- wherein the FAS inhibitor is selected from the group consisting of an siRNA directed against FASN, an artificial microRNA directed against FASN, an antisense molecule directed against FASN, a ribozyme directed against FASN, and a small molecule directed against FAS.
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Dependencies are inferred from the claim text.