Vitamin receptor drug delivery conjugates for treating inflammation
AssigneeEndocyte, Inc.
InventorsChristopher Paul Leamon, Iontcho Radoslavov Vlahov, Yingjuan June Lu, Kevin Yu Wang, Fei Yu, Paul Joseph Kleindl, Hari Krishna R. Santhapuram
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Abstract
Described herein are compositions, methods, compounds, conjugates, and kits for use in targeted drug delivery using drug delivery conjugates containing hydrophilic spacer linkers for use in treating disease states caused by pathogenic cell populations, such as inflammatory cells.
Claims21
A compound of the formula
- BLA
- or a pharmaceutically acceptable salt thereof;
- wherein
- B is a vitamin receptor binding ligand;
- L is a linker that comprises one or more hydrophilic spacer linkers;
- and
- A is an anti-inflammatory agent.
(canceled).
The compound of claim 3, wherein the antifolate is aminopterin, or an analogue or derivative thereof.
A pharmaceutical composition comprising a compound of the formula
- BLA
- or a pharmaceutically acceptable salt thereof;
- wherein
- B is a vitamin receptor binding ligand;
- L is a linker that comprises one or more hydrophilic spacer linkers;
- and
- A is an anti-inflammatory agent.
A method for treating a patient with an inflammatory disease, the method comprising the step of administering to the patient a compound of the formula
- BLA
- or a pharmaceutically acceptable salt thereof;
- wherein
- B is a vitamin receptor binding ligand;
- L is a linker that comprises one or more hydrophilic spacer linkers;
- and
- A is an anti-inflammatory agent.
Dependencies are inferred from the claim text.