Systems and methods for treating bacterial infection
AssigneeMotif Biosciences Inc.
InventorDavid Huang
Life of this patent
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Abstract
Therapeutic methods, kits, dosing regimens and uses of a medicament comprising iclaprim are provided, for example, for the treatment of bacterial infection. The administration of iclaprim in a fixed amount can achieve a Cmax(ss) below about 800 ng/mL, a T>MIC of between about 30% to about 95% and a ratio of AUC/MIC of about 20 to about 85, and the bacterial infection can be treated. The fixed amount can be about 70 mg to about 100 mg. The bacterial infection treated may be caused, or related to, drug-resistant bacteria including S. pneumoniae, H. influenzae, S. aureus, K. pneumoniae and M. catarrhalis. The bacterial infection may manifest as a skin and skin structure infection, pneumonia, asthma, emphysema and/or other adverse pulmonary conditions.
Claims20
A therapeutic method comprising:
- administering to a subject who has a bacterial infection a pharmaceutical composition comprising an amount of iclaprim,
- wherein administration of the iclaprim achieves a Cmax(ss) below about 800 ng/mL, a T>MIC of between about 30% to about 95% and a ratio of AUC/MIC of about 20 to about 85, and wherein the bacterial infection is related to respiratory bacterial pathogens.
A dosing regimen comprising:
- intravenously administering to a subject who has a bacterial infection a pharmaceutical composition comprising a fixed amount of iclaprim,
- wherein administration of the fixed amount achieves a Cmax(ss) below about 800 ng/mL, a T>MIC of between about 30% to about 95% and a ratio of AUC/MIC of about 20 to about 85, and wherein the bacterial infection is related to respiratory bacterial pathogens.
Dependencies are inferred from the claim text.