Organic compounds

A method for the treatment or prophylaxis of a central nervous system disorder, comprising administering to a patient in need thereof a compound of a Formula I:

• wherein:
• X is —NH— or —N(CH3)—;
• L is selected from O, NH, NRa, and S;
• Z is —CH(O—R1)—, —O— or —C(O)—;
• R1 is H, —C(O)—C1-21 alkyl (e.g., —C(O)—C1-5 alkyl, —C(O)—C6-15 alkyl or —C(O)—C16-21 alkyl), preferably said alkyl is a straight chain, optionally saturated or unsaturated and optionally substituted with one or more hydroxy or C1-22 alkoxy (e.g., ethoxy) groups, for example R1 is C(O)—C3 alkyl, —C(O)C6 alkyl, —C(O)—C7 alkyl, —C(O)—C9 alkyl, —C(O)—C11 alkyl, —C(O)—C13 alkyl or —C(O)—C15 alkyl;
• Ra is:
• halogen, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, or C3-6 cycloalkyl, each of which can be independently substituted with up to three independently selected Rb groups, for example C-1-3haloalkyl or C1-3hydroxyalkyl;
• or
• aryl optionally substituted with up to five independently selected Rb;
• and each Rb is independently selected from H, halogen, NH2, NO2, OH, C(O)OH, CN, SO3, and C1-4 alkyl;
• in free or salt form;
• optionally in an isolated or purified free or salt form;
• wherein the disease or disorder is selected from obsessive-compulsive disorder (OCD), obsessive-compulsive personality disorder (OCPD), general anxiety disorder, social anxiety disorder, panic disorder, agoraphobia, compulsive gambling disorder, compulsive eating disorder, body dysmorphic disorder, hypochondriasis, pathological grooming disorder, kleptomania, pyromania, attention deficit-hyperactivity disorder (ADHD), attention deficit disorder (ADD), impulse control disorder, and related disorders, and pain disorder or conditions associated with pain, such as cephalic pain, neuropathic pain, idiopathic pain, chronic pain, fibromyalgia, and chronic fatigue, and related disorders, opiate dependency, cocaine dependency, amphetamine dependency, alcohol dependency, and combinations thereof.