Methods and drug products for treating alzheimer's disease
AssigneesTakeda Pharmaceutical Company Limited, Zinfandel Pharmaceuticals, Inc.
InventorsAllen D. Roses, Rajneesh Taneja
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Abstract
Provided herein are drug products with low dose pioglitazone for use in the treatment (e.g., delay of onset) of cognitive impairment of the Alzheimer's type. Methods of manufacture thereof are also provided. Further provided are methods of treatment for Alzheimer's disease including administering a drug product with low dose pioglitazone. The methods may include determining whether the subject is at risk of developing Alzheimer's disease based upon the subject's age and TOMM40 523 genotype.
Claims28
-81. (canceled)
A method of treating cognitive decline in a human subject in need thereof, comprising administering to said subject about 0.5 milligrams to about 9 milligrams of pioglitazone.
The method of 90, wherein said subject further does not have an ApoE genotype of ε2/ε2 or ε2/ε3.
Dependencies are inferred from the claim text.