Solid composition of pyrrole carboxamide
AssigneeDaiichi Sankyo Company, Limited
InventorsHideaki Tanabe, Mina Yamada
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Abstract
An object is to provide a solid composition of stabilized pyrrole carboxamide. A means for achieving the object is a solid composition for medical use containing (S)-1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide and an appropriate additive.
Claims18
A solid composition comprising (S)-1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide which is a compound having the following formula (I):
- and lactose hydrate having an average particle diameter in the range of 5 to 50 μm.
A manufacturing method for a solid composition, comprising a step of mixing (S)-1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide with an additive including lactose hydrate having an average particle diameter in the range of 5 to 50 μm.
A method for increasing the rate of dissolution of a solid composition comprising (S)-1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide under physiological conditions, comprising mixing (S)-1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide with lactose hydrate having an average particle diameter in the range of 5 to 50 μm.
A method for increasing the disintegration time of a solid composition comprising (S)-1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide under physiological conditions, comprising mixing (S)-1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide with lactose hydrate having an average particle diameter in the range of 5 to 50 μm.
Dependencies are inferred from the claim text.