Extended, delayed and immediate release formulation method of manufacturing and use thereof

A method for manufacturing a pharmaceutical composition for reducing the frequency of urination, comprising:

• forming a core structure comprising a first active ingredient formulated for immediate release and a second active ingredient formulated for extended release;
• coating the core structure with a delayed release coating to form a coated core structure;
• mixing the coated core structure with a third active ingredient formulated for immediate release and a fourth active ingredient formulated for extended release to form a final mixture, and
• compressing the final mixture into a tablet,
• wherein at least one of the first, second, third and fourth active ingredients comprises an analgesic agent.

A method for manufacturing a pharmaceutical composition for reducing the frequency of urination, comprising:

• forming a core structure comprising a first active ingredient formulated for immediate release and a second active ingredient formulated for extended release;
• coating the core structure with a delayed release coating to form a coated core structure;
• coating the coated core structure with a third active ingredient formulated for immediate release to form a double-coated core structure,
• wherein at least one of the first, second and third ingredients comprises an analgesic agent.

A pharmaceutical composition, comprising:

• a first component comprising an immediate-release subcomponent and an extended-release subcomponent, wherein the first component is formulated to release the subcomponents immediately after administration;
• and
• a second component comprising an immediate-release subcomponent and an extended-release subcomponent, wherein the second component is formulated for a delayed-release of the subcomponents,
• wherein the immediate-release subcomponent and the extended-release subcomponent in the first component each comprises an active ingredient comprising one or more analgesic agents selected from the group consisting of aspirin, ibuprofen, naproxen, naproxen sodium, indomethacin, nabumetone, and acetaminophen, and
• wherein the immediate-release subcomponent and the extended-release subcomponent in the second component each comprises an active ingredient comprising one or more analgesic agents selected from the group consisting of aspirin, ibuprofen, naproxen, naproxen sodium, indomethacin, nabumetone, and acetaminophen.

A pharmaceutical composition, comprising:

• a first component comprising an immediate-release subcomponent, wherein the immediate-release subcomponent comprises an active ingredient comprising acetaminophen in an amount of 5-2000 mg, wherein the first component is formulated to release its subcomponent immediately after oral administration;
• and
• a second component comprising an immediate-release subcomponent and an extended-release subcomponent, wherein the second component is formulated to release its subcomponent after gastric emptying,
• wherein at least one of the immediate-release subcomponent and the extended-release subcomponent in the second component comprises an active ingredient comprising one or more analgesic agents selected from the group consisting of aspirin, ibuprofen, naproxen, naproxen sodium, indomethacin, nabumetone, and acetaminophen.