Curcuphenol compounds for increasing mhc-i expression
AssigneebioMmune Technologies Inc.
InventorsWilfred Jefferies, Reinhard Gabathuler, Raymond Andersen, Lilian Nohara, David Williams
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Abstract
Provided are methods of using curcuphenol compounds to increase expression of major histocompatibility complex class I (MHC-I) antigen in cells, particularly on the surface of diseased cells such as cancer cells, and thereby increase the immunogenicity of the cells. Also provided are pharmaceutical compositions that comprise curcuphenol compounds and methods of use thereof, for instance, to treat various cancers, alone or in combination with other therapies.
Claims20
A method for increasing major histocompatibility complex class I (MHC-1) surface expression in a cell, comprising contacting the cell with a curcuphenol compound wherein optionally MHC-1 surface expression is increased by at least about 10% relative to an untreated control cell.
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Dependencies are inferred from the claim text.