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US 2017/0319502 A1Published application
Pharmaceuticals for Oral Delivery
AssigneeEnteris BioPharma, Inc.
InventorsStephen M. Carl, John Stanley Vrettos, William Stern
Life of this patent
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Abstract
The present invention provides pharmaceutical compositions suitable for oral delivery and methods of treating subjects in need thereof. The pharmaceutical compositions of the present invention enhance bioavailability of at least one compound classified as BCS Class II, BCS Class III or BCS Class IV.
Claims15
A solid oral dosage form comprising:
- a mixture comprising:
- a therapeutically effective amount of at least one active pharmaceutical compound classified as BCS Class III, wherein the compound does not include a peptide bond in the molecular structure of the compound;
- an absorption enhancer;
- and
- coated organic acid particles, wherein the organic acid particles are coated with a water soluble coat;
- an enteric coating;
- and
- a water soluble barrier positioned between the mixture and the enteric coating, thereby separating the mixture from the enteric coating,
- wherein oral administration results in a synergistic increase in a systemic bioavailability of the active pharmaceutical compound when compared to the systemic bioavailability provided by administration of a solid dosage form containing an equal dose of the active pharmaceutical compound without the absorption enhancer and the coated organic acid particles.
6 more elements
A solid oral dosage form comprising:
- a mixture comprising:
- a therapeutically effective amount of at least one active pharmaceutical compound classified as BCS Class II, BCS Class III or BCS Class IV, wherein the compound does not include a peptide bond in the molecular structure of the compound;
- an absorption enhancer;
- and
- coated organic acid particles, wherein the organic acid particles are coated with a water soluble coat;
- an enteric coating;
- and
- a water soluble barrier positioned between the mixture and the enteric coating, thereby separating the mixture from the enteric coating,
- wherein oral administration results in a synergistic increase in a systemic bioavailability of the least one active pharmaceutical compound when compared to the systemic bioavailability provided by administration of a solid dosage form containing an equal dose of the least one active pharmaceutical compound without the absorption enhancer and the coated organic acid particles.
6 more elements
A method of treating a bacterial infection or a viral infection in a subject in need thereof comprising orally administering a solid oral dosage form comprising:
- a mixture comprising:
- a therapeutically effective amount of at least one active pharmaceutical compound classified as BCS Class II, BCS Class III or BCS Class IV, wherein the compound does not include a peptide bond in the compound's molecular structure;
- an absorption enhancer;
- and
- coated organic acid particles, wherein the organic acid particles are coated with a water soluble coat;
- an enteric coating;
- and
- a water soluble barrier positioned between the mixture and the enteric coating, thereby separating the mixture from the enteric coating,
- wherein oral administration results in a synergistic increase in a systemic bioavailability of the least one active pharmaceutical compound when compared to the systemic bioavailability provided by administration of a solid dosage form containing an equal dose of the least one active pharmaceutical compound without the absorption enhancer and the coated organic acid particles.
6 more elements
Dependencies are inferred from the claim text.