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US 2017/0319491 A1Published application
Tamper resistant dosage forms
AssigneesPurdue Pharma L.P., Purdue Pharmaceuticals L.P.
InventorsWilliam H. MCKENNA, Richard O. MANNION, Edward P. O'DONNELL, Haiyong H. HUANG
Life of this patent
Estimating the term…
Abstract
The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.
Claims27
1-169. (canceled)
A cured shaped extended release tablet comprising:
- (1) an opioid or a pharmaceutically acceptable salt thereof,
- (2) at least one low molecular weight polyethylene oxide having, based on rheological measurements, an approximate molecular weight of less than 1,000,000,
- (3) at least one high molecular weight polyethylene oxide having, based on rheological measurements, an approximate molecular weight of 7,000,000, and
- (4) at least one additive;
- wherein said tablet is prepared by a process comprising the steps of:
- (a) forming a shaped pharmaceutical preparation comprising said opioid or pharmaceutically acceptable salt thereof, said low molecular weight polyethylene oxide, said high molecular weight polyethylene oxide, and said at least one additive;
- and
- (b) curing said shaped pharmaceutical preparation by subjecting said preparation to a temperature from about 60° C. to about 90° C. for a time of from about 15 minutes to about 10 hours;
- and
- (c) optionally applying one or more coatings to said shaped pharmaceutical preparation;
- wherein the total combined weight of said high and low molecular weight polyethylene oxides is at least 79% by weight, and said percent by weight is based upon the total weight of said pharmaceutical preparation, not including the combined weight of said coatings.
8 more elements
Dependencies are inferred from the claim text.