Ingestible formulations for transient, noninvasive reduction of gastric volume

A method of treating obesity in a subject in need thereof, comprising:

• ingesting one or more ingestible tablets comprising cross-linked polymers formed in a packed mass within the one or more ingestible tablets into a stomach of the subject,
• wherein the cross-linked polymers comprise a polymer hydrogel comprising carboxymethylcellulose and a carboxylic acid;
• disintegrating an acid-sensitive gelatin coating such that the coating disintegrates in the gastric fluid and the cross-linked polymers disperse in the stomach, wherein the cross-linked polymers are configured to swell upon absorbing at least one of water and gastric fluid to increase in size and reduce a gastric volume of the stomach of the subject;
• and
• maintaining the reduction in gastric volume such that a sensation of fullness is induced in the subject without releasing a drug which induces the sensation.