Floating Zinc Gastric Delivery Compositions

A composition comprising:

• a therapeutically effective oral pharmaceutical dosage form that becomes buoyant upon contact with gastric fluid, the dosage form having therein:
• 2% w/w to 10% w/w of an amino acid source;
• 9% w/w to 45% w/w of a zinc source;
• 10% w/w to 55% w/w of an anionic polymer;
• 1% w/w to 15% w/w of a bicarbonate;
• and
• wherein the dosage form is effective for releasing the amino acid source and zinc from the zinc source while buoyant on gastric fluid.

A method of treating a gastroesophageal condition associated with stomach acid, the method comprising locally delivering zinc and an amino acid to a distal esophagus of a patient by administering to a patient in need thereof:

• a therapeutically effective oral pharmaceutical dosage form that becomes buoyant upon contact with the patient's gastric fluid, the dosage form having therein:
• an active ingredient combination including an amino acid source and a zinc source;
• an anionic polymer;
• an effervescent agent;
• and
• a pH buffer;
• wherein the dosage form releases the active ingredient combination while buoyant on gastric fluid and neutralizes stomach acid while promoting healing of epithelial cells in the distal esophagus.