Implantable cellular and biotherapeutic agent delivery canister
AssigneeNanoVault Medical LLC
InventorsWillard W. Hennemann, Bryan L. Steelman, Thomas J. Webster
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Abstract
The invention relates to a metallic, nanoporous canister used to encapsulate cellular and/or biotherapeutic agents. The device is biocompatible and functions to wholly isolate a therapeutically active agent and/or cells therein. Their implantation, and survival in vivo, permits the local or systemic diffusion of their encapsulated cellular and/or biomolecular and therapeutics factors with the potential to promote repair of damaged or degenerated tissues in mammalian hosts, primarily humans.
Claims20
(1) An implantable canister for containing and delivering metabolically active agents, comprising:
- (a) a metallic shell configured to possess nanoscale through-porous membrane characteristics, the shell defining a first major surface and a second major surface;
- (b) an interior chamber between the first major surface and second major surface;
- and
- (c) means allowing fluid communication with the interior chamber.
(2) The canister of claim 1 further comprising the nanoscale through-porous membrane morphology having a range between approximately 20 nm to 5000 nm, wherein nutrients, oxygen and metabolites are efficiently exchanged and supports canister vascularization when implanted.
(3) The canister of claim 1 wherein the metallic material is selected from the group consisting of cobalt-chromium based alloys, platinum based alloys, titanium based alloys, nickel-titanium based, nickel-cobalt based alloys, and stainless steel based alloys.
(4) The canister of claim 1 wherein the fluid communication means comprises a port.
(5) The canister of claim 4 wherein the port is covered by a re-sealable membrane.
(6) The canister of claim 5 further comprising an extended tube is attached to the port.
(7) The canister of claim 1 further comprising the interior chamber is configured to have internal raised channels.
(8) The canister of claim 7 wherein the internal raised channels are continuous.
(9) The canister of claim7 further comprising a plurality of internal baffles wherein the internal raised channels are separate from each other.
(10) The canister of claim 1 wherein the interior chamber is divided into a plurality of separate and independent internal chambers.
(11) The canister of claim 1 wherein the nanoscale through-porous membrane further comprises a biocontinuous morphology.
(12) An implantable canister for containing and delivering metabolically active agents, comprising:
- (a) a metallic shell configured to possess nanoscale through-porous membrane characteristics, the shell defining a first major surface and a second major surface and a side surface separating the first major surface and the second major surface;
- (b) an interior chamber between the first major surface and second major surface;
- and
- (c) means allowing fluid communication with the interior chamber.
(13) The canister of claim 1 further comprising the nanoscale through-porous membrane morphology has a range between approximately 20 nm to 5000 nm, wherein nutrients, oxygen and metabolites are efficiently exchanged and supports canister vascularization when implanted.
(14) The canister of claim 12 wherein the metallic material is selected from the group consisting of cobalt-chromium based alloys, platinum alloys based, titanium alloys based, nickel-titanium based alloys, and stainless steel based alloys.
(15) The canister of claim 12 wherein the fluid communication means comprises a port.
(16) The canister of claim 15 wherein the port is covered by a re-sealable membrane.
(17) The canister of claim 16 further comprising an extended tube is attached to the port.
(18) The canister of claim 12 further comprising the interior chamber is configured to have internal channels.
(19) The canister of claim 18 wherein the internal channels are continuous.
(20) The canister of claim 18 further comprising a plurality of internal baffles wherein the internal channels are separate from each other.