High molecular weight polylactide and polycaprolactone copolymer and blends for bioresorbable vascular scaffolds
AssigneeAbbott Cardiovascular Systems Inc.
InventorsXiao Ma, Mary Beth Kossuth, James P. Oberhauser, Stephen D. Pacetti, Manish Gada
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Abstract
Bioresorbable polymer vascular scaffolds made of combinations of polylactide and polycaprolactone having a high molecular weight polymer, thin struts in a selected range and sufficient radial strength to support a vessel upon deployment. The scaffolds have degradation behavior of molecular weight, radial strength, and mass that are conducive to healing of a vessel including providing patency to a vessel, reduction of radial strength, breaking up, and resorbing to allow return of the vessel to a natural state.
Claims11
(canceled)
A stent comprising:
- a bioresorbable polymer scaffold comprising a polymer combination including a polylactide polymer and polycaprolactone,
- wherein the polymer combination is a random copolymer of poly(L-lactide)(PLLA) and polycaprolactone,
- wherein the scaffold includes a plurality of interconnected struts,
- wherein the scaffold is made of at least 95 wt % of the polymer combination,
- wherein a thickess of the struts is 80 to 100 microns and a width of the struts is 200 to 250 microns, and
- wherein the scaffold has a crimped state and a deployed state and a radial strength of the scaffold when expanded from the crimped state to the deployed state in saline or bodily fluid at 37° C. is at least 650 mm Hg.
A stent comprising:
- a bioresorbable polymer scaffold comprising a polymer formulation including a random copolymer of poly(L-lactide) (PLLA) polymer and polycaprolactone (PCL),
- wherein the scaffold includes a plurality of interconnected struts,
- wherein a thickess of the struts is 80 to 100 microns and a width of the struts is 200 to 250 microns,
- wherein a number average molecular weight (Mn) of the blend is greater than 60 kDa, and
- wherein the scaffold has a crimped state and a deployed state and a radial strength of the scaffold when expanded from the crimped state to the deployed state in saline or bodily fluid at 37° C. is at least 650 mm Hg.
Dependencies are inferred from the claim text.