Systems and Methods for Producing Gastrointestinal Tissues at an Anstomosis or Other Physiological Location

A method, comprising the steps of:

• resecting a portion of a tubular organ in a subject, the tubular organ being proximate to the stomach region of the subject, the resection step producing a resected organ portion located primarily in the esophageal region, the resected organ portion remaining in the subject;
• implanting a synthetic scaffold at the site of resection, the synthetic scaffold including a body member, the body member having a tubular region having a first end and a second end opposed to the first end and an outwardly flared region contiguously connected to the tubular region of the body member at a location proximate to one of the first end or second end, an outer polymeric surface and a cellularized sheath layer overlying at least a portion of the outer polymeric surface, wherein the flared region is connected to the stomach and the tubular region is connected to the resected organ portion;
• maintaining the synthetic scaffold at the resection site for a period of time sufficient to achieve guided tissue growth along the synthetic scaffold, the guided tissue growth derived from and in contact with the tissue present in the resected organ portion remaining in the subject;
• and
• after achieving guided tissue growth, removing the synthetic scaffold from the implantation site, the removing step occurring in a manner such that the guided tissue growth remains in the contact with the resected portion of the tubular organ remaining in the subject.