System and method for spectroscopic magnetic resonance fingerprinting
AssigneeCase Western Reserve University
InventorsCharlie Y. Wang, Mark A. Griswold, Xin Yu
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Abstract
The present disclosure relates to a method for performing phosphorous-31 spectroscopic magnetic resonance fingerprinting (MRF). The method comprises performing a pulse sequence using a series of varied sequence blocks to a volume in a subject where the volume contains phosphate metabolites. A series of signal evolutions are acquired from the volume in the subject to form MRF data. The MRF data is then compared to simulated MRF signal to determine parameters associated with phosphate metabolites and the chemical exchange rates between these metabolites. These parameters and exchange rates can be used in diagnosing a metabolic disorder in a subject.
Claims20
A method for performing phosphorous spectroscopic magnetic resonance fingerprinting (MRF) comprising:
- performing a pulse sequence using a series of varied sequence blocks to a volume in a subject, the volume containing one or more metabolites;
- acquiring a series of signal evolutions from the volume in the subject to form MRF data;
- determining parameters associated with phosphate metabolites and chemical exchange rates between these metabolites by comparing the MRF data to simulated MRF signal;
- and
- identifying metabolic alterations in the subject based on the determined parameters.
A method for performing spectroscopic magnetic resonance fingerprinting (MRF) comprising:
- performing a pulse sequence using a series of varied sequence blocks to a volume in an object, the volume containing one or more metabolites;
- acquiring a series of signal evolutions from the volume in the object to form MRF data, wherein the signal evolutions are positioned in a pass-band;
- characterizing the one more metabolites by comparing the MRF data to simulated MRF signal;
- and
- determining at least one metabolite parameter.
A system comprising:
- a magnet system configured to generate a polarizing magnetic field about at least a portion of a subject;
- a magnetic gradient system including a plurality of magnetic gradient coils configured to apply at least one magnetic gradient field to the polarizing magnetic field;
- a radio frequency (RF) system configured to apply an RF field to the subject and to receive magnetic resonance signals from the subject using a coil array;
- a computer system programmed to:
- control the magnetic gradient system and the RF system to perform a pulse sequence using a series of varied sequence blocks to a volume in a subject, the volume containing one or more metabolites;
- acquire a series of signal evolutions from the volume in the object to form MRF data, wherein the signal evolutions are positioned in a pass-band;
- characterize the one more metabolites by comparing the MRF data to an MRF dictionary;
- and
- determine at least one metabolite parameter, wherein the at least one metabolite parameter is used to diagnose a metabolic disorder in the subject.
Dependencies are inferred from the claim text.