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US 2017/0312284 A1Published application
Analogs of adenosine monophosphate (amp) as inhibitors of ubiquitin-like modifier-activating enzyme atg7
AssigneeNorthwestern University
InventorsAlexander V. Statsyuk, Heeseon An
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Abstract
Disclosed are analogs of adenosine monophosphate (AMP) as inhibitors of ubiquitin-like modifier-activing enzyme ATG7. The AMP analogs may be formulated as pharmaceutical compositions for treating diseases or disorders that depend on ATG7 activity and/or autophagy such as cell proliferative diseases and disorders.
Claims18
A compound having a Formula I:
- wherein:
- EG is an electrophilic group,
- m is an integer selected from 0-6,
- n is an integer selected from 0-6, and
- HG is a hydrophobic group.
2 more elements
The compound of claim 1 having a Formula IA:
- wherein:
- X is C, N, O, or S;
- Y is an electrophile;
- n is an integer from 0-6;
- and
- HG is a hydrophobic group.
3 more elements
The compound of claim 4, wherein Y and X form an unsaturated heterocycle selected from
Dependencies are inferred from the claim text.