Rhinovirus C Immunogenic Peptides
AssigneesWisconsin Alumni Research Foundation, Purdue Research Foundation
InventorsAnn C. Palmenberg, Marchel Goldsby Hill, Kelly Elizabeth Watters, Michael G. Rossman, Yue Liu
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Abstract
A peptide comprising the rhinovirus immunogen peptide of the rhinovirus structural protein 1 (VP1) of rhinovirus C and related vaccines and therapeutic compositions is disclosed.
Claims28
A peptide comprising the rhinovirus immunogen peptide of the rhinovirus structural protein 1 (VP1) of rhinovirus C, wherein the peptide does not comprise flanking sequence with which the peptide is contiguous in a naturally occurring rhinovirus.
An antibody or antibody binding fragment thereof which binds to the epitope comprising SEQ ID NO:
- 1.
A monoclonal antibody which recognizes VP1 of rhinovirus C, wherein the epitope that binds or is recognized by said antibody is within SEQ ID NO:1 or a corresponding sequence listed in Table 1.
A hybridoma cell line that produces a monoclonal antibody that binds to SEQ ID NO:
- 1 or a corresponding sequence listed in Table 1.
A method for immunizing a subject against rhinovirus infection, comprising providing to a subject an effective amount of an immunogenic composition comprising an isolated preparation of empty Rhinovirus C particles.
Dependencies are inferred from the claim text.