Synthesis of water-soluble thiolate-protected gold nanoparticles of uniform size and conjugates thereof
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsMaia Azubel, Roger D. Kornberg
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Abstract
Methods of synthesizing water-soluble thiolate-protected gold nanoparticles of uniform size and conjugates thereof are disclosed. In particular, the invention relates to a method of synthesizing homogeneous, water-soluble gold nanoparticles by using a modified Brust procedure and methods of conjugating them. Gold nanoparticles, produced by the methods of the invention, are useful in various therapeutic and imaging applications where the use of gold nanoparticles having uniform structural and optical properties is desired.
Claims21
A method of synthesizing gold nanoparticles, the method comprising:
- adding a thiol and chloroauric acid to a mixture of methanol and water, adjusting pH of the mixture to about 13-14, equilibrating the mixture for at least 14 hours, and reacting with borohydride, whereby gold nanoparticles of uniform size are produced.
Dependencies are inferred from the claim text.