Methods of treating rsv infections
AssigneesAblynx N.V., Vectura Limited
InventorsKoen ALLOSERY, Erik DEPLA, Martin HUBER, Tobias KOLB, Bernhard MÜLLINGER, Massimiliano GERMANI, Juliane SCHICK, Maria-Laura SARGENTINI
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Abstract
Methods are provided for the treatment of RSV infections in young children. More specifically, methods are provided wherein polypeptides that bind F protein of hRSV and that neutralize RSV infection are administered to the lungs of young children at specific dose regimens.
Claims26
-75. (canceled)
A method for treating a respiratory syncytial virus (RSV) infection in a young child, the method comprising the following step:
- administering to the subject a polypeptide that binds a protein of human RSV (hRSV), wherein the protein is glycoprotein F (F-protein), wherein the polypeptide is administered by inhalation at an inhaled dose of 0.020-0.040 mg/kg daily, a deposited dose of 0.020-0.040 mg/kg daily, or a nominal dose of 1.00-2.00 mg/kg daily.
A nebulizer comprising a composition, wherein the composition comprises a polypeptide at a concentration of 50 mg/ml, wherein the composition is present in the neubulizer at a volume of from about 0.100 mL to about 0.500 mL, wherein the polypeptide binds a protein of human RSV (hRSV), wherein the protein is glycoprotein F (F-protein).
Dependencies are inferred from the claim text.