Bone gel sheet composition and method of manufacture
AssigneeVivex Biomedical, Inc.
InventorsWendy W. Weston, Silvia Daniela Gonzales, Edgar S. Maldonado
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Abstract
A bone gel composition consists of cortical bone. The cortical bone is made from cut pieces freeze-dried then ground into particles and demineralized then freeze-dried. A volume of the particles is placed in a solution of sterile water to create a mixture, the water volume being at least twice the particle volume, the mixture is autoclaved under heat and pressure to form a gelatin, the resulting bone gel is formed into sheets having a thickness (t).
Claims22
A bone gel composition consisting of cortical bone consists of cortical bone made from cut pieces freeze dried then ground into particles and demineralized then freeze-dried, wherein a volume of the particles is placed in a solution of sterile water to create a mixture, the water volume being at least twice the volume of the particles, the mixture is autoclaved under heat and pressure to form a gelatin, the resulting bone gel is formed into sheets having a thickness (t).
A method of making a bone gel composition consisting of cortical bone comprises the steps of:
- preparing cortical bone by cutting the cortical bone into pieces, freeze-drying the pieces and then grinding into particles and demineralizing the ground particles and the freeze-drying the demineralized ground particles to form DBM particles;
- autoclaving a volume of the DBM particles mixed with sterile water in a 2:1 ratio by volume for a predetermined time at a pre-set temperature and pressure to form a gelatin;
- cooling the gelatin to form a bone gel;
- forming the bone gel into sheets of bone gel of a thickness (t);
- and
- freezing or packaging the sheets of bone gel, wherein the sheets of bone gel are frozen either before or after packaging.
Dependencies are inferred from the claim text.