Time-controlled glucose releasing hydrogels and applications thereof
AssigneesCentre National de la Recherche Scientifique (CNRS), Universite Paris Diderot—Paris 7, Universite Cergy-Pontoise, Institut National De La Sante Et De La Recherche Medicale (Inserm)
InventorsMickael Deschepper, Hervé Petite, Delphine Logeart Avramoglou, Joseph Paquet, Emmanuel Pauthe, Laurent Bidault, Véronique Larreta Garde
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Abstract
The present invention relates generally to a hydrogel releasing glucose in a time-controlled manner, to medical applications thereof, and to a method for preparing said hydrogel.
Claims21
-16. (canceled)
A time-controlled glucose releasing hydrogel, comprising:
- a) a water-containing gelified polymer;
- b) a glucose polymer entrapped in polymer a);
- and
- c) at least one enzyme capable of hydrolyzing the glucose polymer b) into glucose, said enzyme being entrapped in polymer a).
A method for treating a disorder in a subject in need thereof, comprising:
- (i) administering to said subject a time-controlled glucose releasing hydrogel, comprising:
- a) a water-containing gelified polymer;
- b) a glucose polymer entrapped in polymer a);
- and
- c) at least one enzyme capable of hydrolyzing the glucose polymer b) into glucose, said enzyme being entrapped in polymer a);
- or
- (ii) using on said subject a medical device comprising a time-controlled glucose releasing hydrogel, comprising:
- d) a water-containing gelified polymer;
- e) a glucose polymer entrapped in polymer d);
- and
- f) at least one enzyme capable of hydrolyzing the glucose polymer e) into glucose, said enzyme being entrapped in polymer d).
A method of tissue regeneration in a subject in need thereof, comprising:
- (i) administering to said subject a time-controlled glucose releasing hydrogel, comprising:
- a) a water-containing gelified polymer;
- b) a glucose polymer entrapped in polymer a);
- and
- c) at least one enzyme capable of hydrolyzing the glucose polymer b) into glucose, said enzyme being entrapped in polymer a);
- or
- (ii) using on said subject a medical device comprising a time-controlled glucose releasing hydrogel, comprising:
- d) a water-containing gelified polymer;
- e) a glucose polymer entrapped in polymer d);
- and
- f) at least one enzyme capable of hydrolyzing the glucose polymer e) into glucose, said enzyme being entrapped in polymer d).
A kit, comprising:
- d) a water-soluble gellable monomer or polymer;
- e) a glucose polymer;
- and
- f) at least one enzyme capable of hydrolyzing the glucose polymer b) into glucose.
Dependencies are inferred from the claim text.